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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Historical animal data is provided in a review of nitro-phenols.
The testing listed was performed in 1977
Animal data suggest classification as Skin Irrit 2

Data source

Reference
Reference Type:
review article or handbook
Title:
Concise International Chemical Assessment Document 20
Author:
World Health Organisation
Year:
2000
Bibliographic source:
International Programme on Chemical Safety, Concise International Chemical Assessment Document 20

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-nitrophenol
EC Number:
202-811-7
EC Name:
4-nitrophenol
Cas Number:
100-02-7
Molecular formula:
C6H5NO3
IUPAC Name:
4-Nitrophenol
Test material form:
solid: crystalline
Specific details on test material used for the study:
Not specified in the review

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
Two tests are reported; one was applied as 10% in water and one neat
Duration of treatment / exposure:
Assumed 24 hours
Observation period (in vivo):
At least 72 hours
Number of animals or in vitro replicates:
Not specified in the review

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
animal: mean score
Time point:
24/48/72 h
Score:
6
Reversibility:
fully reversible
Irritant / corrosive response data:
Few details specified in the review, but conclusion was irritating and not causing eye damage
Other effects:
Not specified in the review

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria
Conclusions:
Classified in Annex VI of CLP as Eye Dam 1
No evidence has been found to support this classification

Two studies are cited in the review with one causing no irritation to rabbits when applied dilute, but moderate irritation when applied undiluted
The scoring system used is unclear, but the conclusion is that on the basis of the data presented, the substance is irritating to eyes