Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 430-760-2 | CAS number: 219861-18-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Guidance on Safe Use
Administrative data
First-aid measures
General information: When seeking medical attention, show this material safety data sheet or the packing with the label.
After inhalation: Immediately remove patient from exposure and move to fresh air. Rinse mouth and nose with water. Obtain medical attention if irritation persists.
After skin contact: Remove contaminated clothing. Wash affected area with plenty of water and soap. Obtain medical attention if irritation persists.
After eye contact: Remove contact lenses if any. Immediately rinse affected eye(s) with water for up to 15 minutes. Obtain medical attention if irritation/discomfort persists.
Continue to rinse with water during transport.
After swallowing: Flush mouth with water and give milk or water to conscious person. Try to induce vomiting. Obtain medical attention. In case of unconsciousness provide
artificial respiration.
Fire-fighting measures
Suitable extinguishing agents: Extinguish fire with water, dry chemical, CO2 or foam.
Special hazards arising from the substance or mixture Formation of toxic and corrosive gases is possible during heating or in case of The substance is combustible and the dust may form explosive mixtures with air.
Protective equipment: A self-contained breathing apparatus and full protective clothing should be worn when fighting the fire.
Additional information Evacuate area.
Remove substance/product from fire threatened area, if possible.
Stop leakage. Water from extinction of fires may be hazardous waste. Must not enter sewage or water systems.
Avoid inhalation of fumes. Persons who have inhaled fumes must obtain medical attention (risk of delayed lung oedema).
Accidental release measures
Personal precautions, protective equipment and emergency procedures Use respirator, protective gloves and goggles/face shield during clean-up.
Avoid contact with skin and eyes and inhalation of dust.
Environmental precautions: Do not allow product to reach sewage system or any water course.
Methods and material for containment and cleaning up: Small release: Wipe up spillages with moist cloth or paper.
Major release: Pick up mechanically and dispose of according to regulation on hazardous waste.
Dust generation may be reduced by carefully moistering or by covering with plastic film.
Wash the spillage area with plenty of water, and prevent entry into drains.
Handling and storage
Precautions for safe handling Persons, who handle this material, should be familiar with the hazards of the material and the necessary safety precautions, including this safety data sheet.
Pregnant and breast feeding women should not be exposed to the substance.
Persons under 18 years of age may not work with or be exposed to the substance.
The substance should preferable be used in closed systems and be handled under well-ventilated conditions.
Immediately remove contaminated clothes.
Wash hands after work, before eating and after using the bathroom.
Avoid inhalation of dust. Avoid contact with skin and eyes. Avoid prolonged and/or repeated exposure.
Prevent formation of dust.
Information about fire - and explosion
protection: If hazardous, explosive atmospheres may form, the work area must be classified and organised according to the regulations on hazardous, explosive
atmosphere. All work must be carried out in compliance with these regulations.
Dust can combine with air to form an explosive mixture (dust explosion).
Storage: Store in a well-closed container.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- 3077
Shipping information
- Proper shipping name and description:
- 3077 ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. ((R)-4-(4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl) benzonitrile)
- Chemical name:
- (R)-4-(4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl) benzonitrile)
- Labels:
- 9
SpecialProvisionsopen allclose all
Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- 3077
Shipping information
- Proper shipping name and description:
- 3077 ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. ((R)-4-(4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl) benzonitrile)
- Chemical name:
- (R)-4-(4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl) benzonitrile)
- Labels:
- 9
Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
- UN number:
- 3077
Shipping information
- Proper shipping name and description:
- 3077 ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. ((R)-4-(4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl) benzonitrile)
- Chemical name:
- (R)-4-(4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl) benzonitrile)
- Labels:
- 9
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- 3077
Shipping information
- Proper shipping name and description:
- 3077 ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. ((R)-4-(4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl) benzonitrile)
- Chemical name:
- (R)-4-(4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl) benzonitrile)
- Labels:
- 9
Remarksopen allclose all
SpecialProvisionsopen allclose all
Exposure controls / personal protection
The substance is used under strictly controlled condition (SCC) during its whole lifecycle:
(a) the substance is rigorously controlled from its arrival to its use and transformation:
(b) procedural (Standard Operating Procedures for use) and control technologies are used to minimize emission and any resulting exposure;
(c) the substance is handled only by trained and authorized personnel;
(d) in the case of cleaning and maintenance works, special procedures such as equipment washing are applied before the system is opened and entered;
(e) in cases of accident and where waste is generated, there is an Emergency Plan to minimize emissions and the resulting exposure;
(f) substance-handling procedures are well documented and strictly supervised by the site operator.
Stability and reactivity
Chemical stability Stable at normal temperature and pressure.
Possibility of hazardous reactions The substance is expected to be combustible. Dust may form explosive mixtures with air.
Conditions to avoid No further relevant information available.
Incompatible materials: No further relevant information available.
Hazardous decomposition products: Formation of toxic and corrosive gases is possible during heating or in case of fire (COx, NOx).
Disposal considerations
The product should be disposed of according to local regulations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.