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REACH

Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, 2-ethylhexyl ester

EC number: 807-747-9 | CAS number: 144429-84-5

Life Cycle description
Uses advised against

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Assessment of source substance (EC 406 -040 -9):

Test organism	Test duration	Effect parameter	Effect value (mg/L)	Nominal/ measured	OECD guideline	Vehicle	Year of the study	Remarks
Brachydanio rerio	96h	LC50	>100	nominal	203	yes	1989	No effects in the range of solubility
Oncorhynchus mykiss	14d	NOEC	>=100	nominal	204	no	2000	No effects in the range of solubility
Brachydanio rerio	35d	NOEC	>=0.001	nominal	210	yes	2007	No effects in the range of solubility
Daphnia magna	48h	LC50	>100	nominal	202	no	2002	No effects in the range of solubility
Daphnia magna	21d	NOEC	1:3.2 dilution	loading rate 100mg/L	211	no	2000	Effects at the highest test concentration
Daphnia magna	21d	NOEC	>= 1mg/L	loading rate 1mg/L	211	no	2012	No effects in the range of solubility
Scenedesmus subspicatus	72h	LC50 NOEC	>3 >= 3	nominal	201	yes	1995	No effects in the range of solubility
Activated sludge	3h	EC50	> 100mg/L	nominal	209	no	1989

Assessment of target substance:

Test organism	Test duration	Effect parameter	Effect value (mg/L)	Nominal/ measured	OECD guideline	Vehicle	Year of the study	Remarks
Gobiocypris rarus (Chinese Rare Minnow)	96h	LL50	> 100 mg/L	nominal	203	no	2017	No effects in the range of solubility
Activated sludge	3h	EC10	> 1000 mg/L	nominal	209	no	2018

No toxic effects of the test item were observed in the range of solubility. The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations. The substance is with high probability acutely and chronically not harmful to aquatic organisms.

Supporting assessment of major degradation product Metilox acid (CAS 20170-32-5)

Test organism	Test duration	Effect parameter	Effect value	Nominal/measured	OECD guideline	Vehicle	Year of the study	Remarks
Brachydanio rerio	96h	LC50	130 mg/L	nominal	203	yes	1989	A slight deposit was observed at conc. 180-320 mg/l (nominal) from the start of the test.
Daphnia magna	48h	LC50	> 121 mg/L	measured	202	no	2011
Pseudokirchnerella subcapitata	72h	ErC50 ErC10	>100mg/L 95mg/L	nominal	201	no	2009
Activated sludge	3h	EC50	> 100mg/L	nominal	209	no	1988

Acute toxicity test results are available for fish, Daphnia and algae. In an activated sludge respiration inhibition test, no adverse effects were observed. Slight toxic effects were observed in tests with fish and algae. However, these effects were caused by very high concentrations and are above the criteria for classification according to CLP.

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