TETRASODIUM ETHYLENE 1,1-DIPHOSPHONATE

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2002-04-30 - 2002-06-30

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

appearance / physical state / colour

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2002-04-30 - 2002-06-30

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

no guideline required

Principles of method if other than guideline:

Visual inspection

GLP compliance:

yes (incl. QA statement)

Remarks:

2000-04-26

Specific details on test material used for the study:

- Synonyms: ITC 908, vinylidenephosphonic acid tetrasodium salt (VDPA tetrasodium salt)
- Lot/batch No.of test material: 562CH/646
- Purity: 87.33%
- Storage condition of test material: Room temperature, in the dark

Physical state at 20°C and 1013 hPa:

solid

Form:

solid: particulate/powder

Colour:

White

Substance type:

organic

Conclusions:

ITC 908, VDPA tetrasodium salt, is a white solid.

Executive summary:

ITC 908, VDPA tetrasodium salt, is a white solid

Cross-reference 2

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2002-04-30 - 2002-06-30

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient - Shake Flask Method)

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)

GLP compliance:

yes (incl. QA statement)

Remarks:

2000-04-26

Type of method:

flask method

Partition coefficient type:

octanol-water

Specific details on test material used for the study:

- Synonyms: ITC 908, vinylidenephosphonic acid tetrasodium salt (VDPA tetrasodium salt)
- Lot/batch No.of test material: 562CH/646
- Purity: 87.33%
- Storage condition of test material: Room temperature, in the dark

Analytical method:

liquid chromatography

Type:

Pow

Partition coefficient:

< 0.003

Temp.:

21 °C

pH:

ca. 7

Type:

log Pow

Partition coefficient:

< -2.52

Temp.:

21 °C

pH:

ca. 7

Details on results:

Linearity of detector response was assessed for this test in aqueous and organic media. Correlation coefficients of 0.999 were obtained proving satisfactory for the test.

Conclusions:

The partition coefficient of the test material has been determined to be less than 3.03x10-3 at 21 +-0.5°C, log10 Pow < -2.52.

Executive summary:

The partition coefficient of the test material has been determined to be less than 3.03x10-3 at 21 +-0.5°C, log10 Pow < -2.52.

Cross-reference 3

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2002-04-30 - 2002-06-30

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Remarks:

2000-04-26

Type of method:

flask method

Specific details on test material used for the study:

- Synonyms: ITC 908, vinylidenephosphonic acid tetrasodium salt (VDPA tetrasodium salt)
- Lot/batch No.of test material: 562CH/646
- Purity: 87.33%
- Storage condition of test material: Room temperature, in the dark

Water solubility:

> 22 - < 23.9 other: %w/w

Conc. based on:

test mat.

Temp.:

20 °C

pH:

> 10.8 - < 10.9

Key result

Water solubility:

> 282 000 - < 315 000 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

> 10.8 - < 10.9

Conclusions:

The water solubility of the test material has been determined to be in the range 22.0 to 23.9% w/w at 20.0 +- 0.5 °C.

Executive summary:

The water solubility of the test material has been determined to be in the range 22.0 to 23.9% w/w at 20.0 +- 0.5 °C.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2002

Report date:

2002

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

GLP compliance:

yes (incl. QA statement)

Remarks:

2000-04-26

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

443-520-7

EC Name:

-

Cas Number:

33016-77-2

Molecular formula:

C2H4Na4O6P2

IUPAC Name:

tetrasodium (1-phosphonatoethenyl)phosphonate

Test material form:

solid

Specific details on test material used for the study:

- Synonyms: ITC 908, vinylidenephosphonic acid tetrasodium salt (VDPA tetrasodium salt)
- Lot/batch No.of test material: 562CH/646
- Purity: 87.33%
- Storage condition of test material: Room temperature, in the dark

Results and discussion

Melting / freezing point

Melting / freezing pt.:

> 400 °C

Decomposition:

no

Any other information on results incl. tables

The temperature accuracy of the DSC was assessed using an indium reference standard (purity*99.99998%). The melting temperature was determined to be 156.5 °C and within the defined tolerance (156.6 +- 5 °C). The DSC was therefore considered acceptable for use.

Applicant's summary and conclusion

Conclusions:

The melting/freezing temperature of the test material has been determined to be greater than 400 °C.

Executive summary:

The test material appeared as a white solid on completion of testing (i.e. as initial appearance) indicating no physical change had occurred.

The melting/freezing temperature of the test material has been determined to be greater than 400 °C.