Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
The reliability assessment of the prediction is presented in the attached document (QPRF).
Qualifier:
equivalent or similar to guideline
Guideline:
other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.
Specific details on test material used for the study:
CC(=O)N1C2=CC=CC=C2CCC3=CC=CC=C31
Test organisms (species):
other: Fish
Dose descriptor:
LC50
Effect conc.:
16.03 mg/L
Sublethal observations / clinical signs:

The prediction was deemed to be reliable on the basis of the parameters listed above. The molecule falls into the applicability domain of the model.

Validity criteria fulfilled:
yes
Conclusions:
The fish LC50 of the substance was predicted to be 16.03 mg/L.
Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
Documentation about the justification is provided in attachment (See Supporting information). The reliability assessment of the prediction is presented in the attached document as well (QPRF).
Qualifier:
equivalent or similar to guideline
Guideline:
other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.
Specific details on test material used for the study:
CC(=O)N1C2=CC=CC=C2CCC3=CC=CC=C31
Test organisms (species):
other: Fish
Dose descriptor:
LC50
Effect conc.:
> 10 - <= 100 mg/L
Sublethal observations / clinical signs:

The prediction was deemed to be reliable on the basis of the parameters listed above. The molecule falls into the applicability domain of the model.

Validity criteria fulfilled:
yes
Conclusions:
The fish LC50 of the substance was predicted to be between 10 and 100 mg/L

Description of key information

Based on the weight of evidence, fish LC50 is predicted to fall between 10 - 100 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
16.03 mg/L

Additional information