Registration Dossier
Registration Dossier
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EC number: 840-270-4 | CAS number: 13080-75-6
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, and documentation / justification is limited
- Justification for type of information:
- The reliability assessment of the prediction is presented in the attached document (QPRF).
Data source
Reference
- Reference Type:
- other: QSAR model
- Title:
- VEGA in silico platform v.1.1.5
- Year:
- 2 019
- Bibliographic source:
- Carcinogenicity oral classification model (IRFMN) 1.0.0
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.
Test material
- Details on test material:
- The SMILES included in the reference substance linked in Section 1 (General information) was used as model input.
- Specific details on test material used for the study:
- CC(=O)N1C2=CC=CC=C2CCC3=CC=CC=C31
Results and discussion
Effect levels
- Remarks on result:
- other: The substance is predicted to be NON carcinogen
Any other information on results incl. tables
The prediction was deemed to be not reliable on the basis of the parameters listed above. The molecule does not fall into the applicability domain of the model.
Applicant's summary and conclusion
- Conclusions:
- The substace is predicted to be NON carginogen.
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