4H-Pyrazino[2,1-a]isoquinolin-4-one, 2-acetyl-1,2,3,6,7,11b-hexahydro-

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

07.01.2004 - 06.02.2004

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

Regulation 92/69/EWG from 29.12.1992

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

capillary method

Key result

Melting / freezing pt.:

142 °C

Atm. press.:

1 013 hPa

Decomposition:

no

Sublimation:

no

As calibration substances 3-methylbenzoic acid and sulfanilamide were measured. The mean melting point for the 3-methylbenzoic acid was 111.9 °C, which corresponds with the literature value (112 °C) and for sulfanilamide was 164.9 °C also corresponding with the literature value (165.1 °C).

The melting point of the test item at atmospheric pressure was determined to be 142 °C.

Table 1: Measured data on the melting point

Melting point in°C			Mean value	Standard deviation in°C
Replicate 1	Replicate 2	Replicate 3
141.8	141.9	142.4	142.0	±0.3

Conclusions:

The melting point of the test item was determined to be 142 °C at 1013 hPa.

Executive summary:

A study was conducted according Regulation 92/69/EWG from 29.12.1992 method A.1 to determine the melting point of the test item using the capillary method. In a preliminary test using a linear heating rate of 10 °C/min the preliminary melting point of the test item was determined. For the main test, a small amount of test item was charged in capillary glass tubes and packed tightly to obtain a filling level of approximately 4 - 5 mm. Three capillaries were prepared. Heating was started from 138 °C with heating rate of 0.5 °C/min. The melting point of the test item was determined to be 142.0 °C at 1013.25 hPa.

Description of key information

The melting point of the test item was determined to be 142 °C at 1013 hPa.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

142 °C

Additional information

A study was conducted according Regulation 92/69/EWG from 29.12.1992 method A.1 to determine the melting point of the test item using the capillary method. In a preliminary test using a linear heating rate of 10 °C/min the preliminary melting point of the test item was determined. For the main test, a small amount of test item was charged in capillary glass tubes and packed tightly to obtain a filling level of approximately 4 - 5 mm. Three capillaries were prepared. Heating was started from 138 °C with heating rate of 0.5 °C/min. The melting point of the test item was determined to be 142.0 °C at 1013.25 hPa (reference 4.2-1).