Registration Dossier
Registration Dossier
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EC number: 443-100-3 | CAS number: 138679-81-9 PCH-3H.F
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 OCT 2005 - 09 JAN 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- Guideline 67/548/EEC
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Water solubility:
- 9.74 µg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 5.07
- Remarks on result:
- other: refer to "Remarks"
- Remarks:
- The water solubility of the test item was determined without correction for the purity
- Conclusions:
- The water solubility of the test item at a temperature of 20°C is 9.74 ±1.63 µg/L (without correction for the purity).
- Executive summary:
The water solubility of the test item was tested according to EU Method A.6 and OECD Guideline 105 in a GLP study. The water solubility of the test item at a temperature of 20°C is 9.74 ±1.63 µg/L (without correction for the purity).
Reference
Preliminary Visual Estimation of the Water Solubility
The preliminary visual experiments showed that the water solubility of the test item is below 8.44 mg/L. Therefore the water solubility had to be determined by the column elution method.
Column elution method
The coating check was successful.
According to the guideline, the data of the fractions 1 to 5 were not taken into account for the following evaluation. The values for the water solubility were calculated from fractions 25 to 29 for column 1, from the fractions 50 to 54 for column 2, from the fractions 22 to 26 for column 3. All other fractions were discarded.
Result run 1: Evaluation of the fractions 25 to 29. The water solubility was found to be: 8.59 µg/L ± 0.82 g/L (without correction of the purity)
Result run 2: Evaluation of the fractions 17 to 21. The water solubility was found to be: 10.90 µg/L ± 0.99 µg/L (without correction of the purity)
Result run 3: Evaluation of the fractions 22 to 26. The blank concentration was found to be < 7.53 µg/L
Recoveries of the 'Recheck sample' ranged between 99.9 % and 104.5 %, indicating a good accuracy of the analytical method.
Description of key information
The water solubility of the test item was tested according to EU Method A.6 and OECD Guideline 105 in a GLP study. The water solubility of the test item at a temperature of 20°C is 9.74 ±1.63 µg/L (without correction for the purity).
Key value for chemical safety assessment
- Water solubility:
- 9.74 µg/L
- at the temperature of:
- 20 °C
Additional information
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