Registration Dossier
Registration Dossier
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EC number: 952-948-8 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 November 2019 to 19 December 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Purity: 94.5%
Storage: In darkness at room temperature.
Identification: number 19-194. - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.4
- Temp.:
- 25 °C
- pH:
- ca. 6.5
- Conclusions:
- Using Guideline EC A.24. method (2016) and OECD Guideline No. 117 (2004) it was shown that the the octanol/water partition coefficient of 3-Bromo-1-(3-Chloro-2-Pyridyl)-5-Methyl-1H-Pyrazole is equal to 2.4.
- Executive summary:
The objective of this study was to determine the partition coefficient of 3-BROMO-1-(3- CHLORO-2-PYRIDYL)-5-METHYL-1H-PYRAZOL following the Regulation (EC) No.1907/2006 - and Council regulation (EC) No. 2016/266 - EC A.24. method (2016) using the HPLC test method OECD Guideline No. 117 (2004). Using these guidelines, it was shown that the octanol/water partition coefficient of 3 -Bromo-1-(3-Chloro-2-Pyridyl)-5-Methyl-1H-Pyrazole is equal to 2.4 which is in accordance with the solubility in organic solvents..
Reference
Description of key information
The objective of this study is to determine the partition coefficient of 3-Bromo-1-(3-Chloro-2-Pyridyl)-5-Methyl-1H-Pyrazole following the Regulation (EC) No.1907/2006 - and Council regulation (EC) No. 2016/266 - EC A.24. method (2016) and using the HPLC test method OECD Guideline No. 117 (2004). Using these guidelines, it was shown that thethe octanol/water partition coefficient of 3-Bromo-1-(3-Chloro-2-Pyridyl)-5-Methyl-1H-Pyrazole is equal to 2.4.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.4
- at the temperature of:
- 25 °C
Additional information
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