1-chloro-2-nitrobenzene

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Individual animal data and information on GLP is missing.

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1991

Reference 2

Reference Type:

other: OECD SIDS

Title:

Unnamed

Year:

2001

Materials and methods

Principles of method if other than guideline:

5 rats/dose (2 male and 3 female, or 3 female and 2 male), single oral dose as 10 % warm solution, observation time: 7 days.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Reference

Name:

Unnamed

Type:

Constituent

Details on test material:

Purity 99.71%

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

Concentration of the test material in the vehicle: 10%.

Doses:

398, 501, 631, 794 mg/kg bw

No. of animals per sex per dose:

5 per dose (2 males and 3 females at 398 and 631 mg/kg bw; 3 males and 2 females at 501 and 794 mg/kg bw).

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

560 mg/kg bw

Based on:

test mat.

Mortality:

398 mg/kg bw: 1 male, 0 females
501 mg/kg bw: 1 male, 1 female
631 mg/kg bw: 2 males, 2 females
794 mg/kg bw: 3 males, 2 females
Time of death: 1-4 days after dosing with most deaths within 2 days.

Clinical signs:

Reduced appetite and activity(2-3 days in survivors), increasing weakness, ocular discharge, collapse.

Gross pathology:

Decedents: hemorrhagic lungs, jaundiced liver, darkened kidneys and spleen, gastrointestinal inflammation.
Survivors: lung congestion and darkened kidneys and spleen.