1-Octadecanaminium,N,N-Dimethyl-N-Octadecyl-,(Sp-4-2)-[29h,31h-Phthalocyanine2-Sulfonato(3-)-N 29,N 30,N 31,N 32]Cuprate(1-)

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

April 11 - April 12, 1989

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

The study was performed according to guidelines and under GLP conditions. Restriction due to variability of 34% in concentration measurement of five consecutive samples (column 1) which did not meet the maximum variability of 30% allowed by the method.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1989

Report date:

1989

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

yes

Remarks:

The test was performed at 21.5 ± 0.5 C. The pH was not measured as each sample was taken from the column. Instead, the pH was measured on an extra 5 mL sample taken after all test samples were taken from the column.

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

The test was performed at 21.5 ± 0.5 C. The pH was not measured as each sample was taken from the column. Instead, the pH was measured on an extra 5 mL sample taken after all test samples were taken from the column.

GLP compliance:

yes

Type of method:

column elution method

Test material

Test material information

Constituent 1

Results and discussion

Water solubility

Water solubility:

0.02 mg/L

Temp.:

21.5 °C

pH:

>= 4.6 - <= 5.1

Details on results:

The mean water solubility of the test sample was determined to be 0.02 mg/L at 21.5 ± 0.5 degrees C. The range of solubilities was 0.0171 to 0.021 mg/L . Details are given in Table 1 in the "Remarks on results" section.

Any other information on results incl. tables

Table 1: Water Solubility Measurements

Column	Sample	Flow mL/hour	pH	Concentration [x10^-6g/L]	Mean ± S.D. [.x10^-6g/L]
1	A	54.0	5.1	17.1
1	B			15.5
1	C			14.0	16.9±2.8
1	D			16.5
1	E			21.4
2	A	54.0	4.6	23.8
2	B			22.4
2	C			24.8	23.1±1.5
2	D			23.6
2	E			21.0

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The mean water solubility of the test material is 0.020 mg/L at 21.5 ± 0.5 degrees C

Executive summary:

Following guidelines OECD 105 and EU method A.6, the water solubility of the test substance was determined by column elution . Based on a preliminary test, it was determined that the column elution method with recirculating pump was the appropriate procedure. The test substance was added to the columns as a slurry in the Celite 545 support , the columns were filled with the slurry to a height of 4 cm then filled with Milli-Q water and circulation started. Recirculation was continued for 24 hours. Samples were taken from both columns for analysis by UV-Vis spectrophotometry. Measurements were continued until 5 consecutive samples showed a constant deviation in concentration. The water solubility of the test material was determined to be 0.020 mg/L at 21.5 ± 0.5 degrees C (the mean of two columns).