(R)-2-(2,5-difluorophenyl)pyrrolidine (R)-2-hydroxysuccinate

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

17 Aug 2021

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2021

Report date:

2021

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: isothermal thermogravimetry

Test material

Test material information

Constituent 1

Results and discussion

Vapour pressure

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

0.005 Pa

Remarks on result:

other: mean of three measurements

Any other information on results incl. tables

The measurement of the vapour pressure was done with the reproducible weight loss values starting from about 1 µg/min and sufficient difference from the melting and degradation point in the temperature range between 40 °C and 70 °C. For the evaluation, the weight losses of the temperature steps between 50 °C and 65 °C have been considered.

The plot of log V_T of the test item as a function of the reciprocal temperatures showed a coefficient of correlation (R²) of 0.9911.

Inserting the equation for log V_T above, the following equation for the temperature dependence of the vapour pressure of the test item is obtained:

logP_T = 5.1909 + 1.1972*(-7442.8 *1/T + 19.109)

With this equation, the following vapour pressure results were obtained:

4.53 x 10^-3 Pa at 20 °C resp. 1.47 x 10^-2 Pa at 25 °C.

Applicant's summary and conclusion

Conclusions:

The isothermal thermogravimetrical effusion method was applied for
the determination of the vapour pressure of the test item. A value of the vapour pressure of the test item was assessed using the data obtained between 50 °C and 65 °C. The vapour pressure of the test item was determined to be
4.53 x 10-3 Pa at 20 °C resp. 1.47 x 10-2 Pa at 25 °C.

Executive summary:

Test Design: The vapour pressure of the test item at 20 °C und 25 °C (P_T, 20 resp. P_T, 25) was determined using the isothermal thermogravimetrical effusion method. According to the guideline, this method was validated in the range 10^-10 to > 1 Pa using a set of reference substances with known vapour pressures. 

 

Results/Conclusion: The isothermal thermogravimetrical effusion method was applied for the determination of the vapour pressure of the test item. A value of the vapour pressure of the test item was assessed using the data obtained between 50 °C and 65 °C. The vapour pressure of the test item was determined to be

4.53 x 10^-3 Pa at 20 °C resp. 1.47 x 10^-2 Pa at 25 °C.