Registration Dossier
Registration Dossier
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EC number: 604-636-5 | CAS number: 148477-71-8
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- In-life initiated/completed: 28-Jan-1998 to 26-Oct-1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Test temperature:
- 20 ± 2°C
- pH:
- 7.0
- Details on test conditions:
- Test concentrations (mg/L): 100; 1000; 10 000
Test substance concentration in physico-chemical oxygen consumption control (mg/L): 10 000
Type of application: direct weighing
Test concentration of the activated sludge: 320 mg/L
Incubation time: 30 minutes with permanent aeration - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Results with reference substance (positive control):
- Reference substance: 3,5-Dichlorophenol
EC50 = 13 mg/L - Reported statistics and error estimates:
- The EC values were determined by statistical methods: probit analysis
- Conclusions:
- Toxicity to activated sludge: EC50 > 10000 (mg/L)
- Executive summary:
The substance causes no effect to the bacterial population, therefore no damage of the selfpurification of the surface water is to be expected.
Reference
Description of key information
Activated sludge containing the test material (mixed population of different micro-organisms) was exposed for 3 hours to nominal concentrations of 100, 1000 and 10000 mg/L. The EC50 was determined as >10000 mg/L, indicating no activity of spirodiclofen on activated sludge.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 10 000 mg/L
Additional information
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