Registration Dossier
Registration Dossier
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EC number: 242-665-1 | CAS number: 18912-80-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VIII
- Author:
- Carpenter C.P., Weil C.S., Smyth H.F.
- Year:
- 1 974
- Bibliographic source:
- Toxicology and Applied Pharmacology 28, 313-319
- Reference Type:
- publication
- Title:
- Range finding toxicity data: List VI
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel BS
- Year:
- 1 962
- Bibliographic source:
- Am Ind Hyg Ass J, 23, 95
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- Study predates guideline but follows basic principles
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-[2-(2-methylpropoxy)ethoxy]ethanol
- EC Number:
- 242-665-1
- EC Name:
- 2-[2-(2-methylpropoxy)ethoxy]ethanol
- Cas Number:
- 18912-80-6
- Molecular formula:
- C8H18O3
- IUPAC Name:
- 2-[2-(2-methylpropoxy)ethoxy]ethan-1-ol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: own colony
- Age at study initiation: 4-5 weeks
- Weight at study initiation: 90-120g
- Fasting period before study: not fasted.
- Diet (e.g. ad libitum): Rockland diet
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Not specified but arranged logarithmically by a factor of 2
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Remarks:
- large number of other substances tested in same study.
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- Calculation by method of Thomson (1947) using tables of Weil (1952)
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 920 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 3.58 - <= 6.78
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
In an old but reasonably well reported acute oral toxicity study, the LD50 of the substance was determined to be 4920mg/kgbw, with a 95% confidence interval of 3.58 to 6.78mg/kgbw.
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