Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- September 202 - January 2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Principles of method if other than guideline:
- The test item is not stable and hydrolyses within a few minutes when in contact with water: Therefore, it was decided to measure the partition coefficient of the degradation product itself.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- - Storage conditions: Keep in a cool dry place. Store under nitrogen at room temperature; keep away from any humidity and sunlight.
- Key result
- Water solubility:
- 276 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 500 g/L
- Incubation duration:
- 24 - 72 h
- Temp.:
- 20 °C
- pH:
- 2.85
- Details on results:
- After a shaking time of 24 hours, 48 hours and 72 hours, respectively, at 30 °C, the samples were equilibrated for another 96 hours at 20 °C. Afterwards, the samples were centrifuged, diluted and analysed by HPLC with UV-detection. The pH value in the samples was measured to be at about 2.8 to 2.9.
- Conclusions:
- The water solubility of LZ 399 was found to be 276 ± 16 g/L at 20°C.
- Executive summary:
The water solubility was measured according to OECD test method no. 105, using the flask shake method with HPC/UV-detection. The substance to be registered is not stable and hydrolyses within a few minutes when in contact with water: Therefore, it was decided to measure the water solubility of the degradation product itself. The water solubility of LZ 399 was found to be 276 ± 16 g/L at 20°C..
- Endpoint:
- water solubility
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- The test item is not stable and hydrolyses in less than one minute when in contact with water: Therefore, it was decided to measure the water solubility of the degradation product (see separate RA source robust summary). The water solubility of the Zinc Chelate Complex was estimated.
- Key result
- Water solubility:
- ca. 100 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- Remarks on result:
- other: water solublity was estimated due to hydrolysis in contact with water
- Conclusions:
- The water solubility of the test item was estimated to be ca. 100 mg/l at 20°C.
- Executive summary:
The test item is not stable and hydrolyses in less than one minute when in contact with water: Therefore, it was decided to measure the partition coefficient of the degradation product (see separate RA source robust summary). The water solubility of the test item was estimated to be ca. 100 mg/l at 20°C.
- Endpoint:
- water solubility
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance is hydrolytically unstable at pH 4, 7 and 9 (half-life less than 12 hours)
Referenceopen allclose all
Description of key information
The water solubility was measured according to OECD test method no. 105, using the flask shake method with HPC/UV-detection. The substance to be registered is not stable and hydrolyses within a few minutes when in contact with water: Therefore, it was decided to measure the water solubility of the degradation product. The water solubility of the degradation product LZ 399 was found to be 276 ± 16 g/L at 20°C, whereas the the water solubility of the Zinc Chelate Complex was estimated to be approx. 100 mg/l.
Key value for chemical safety assessment
- Water solubility:
- 276 g/L
- at the temperature of:
- 20 °C
Additional information
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