Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: evaluation of available data
- Justification for type of information:
- Justification for read-across is attached in Section 13 of IUCLID
Data source
Reference
- Reference Type:
- other: assessment of available data
- Title:
- Unnamed
- Year:
- 2 023
Materials and methods
- Principles of method if other than guideline:
- evaluation of available data
- GLP compliance:
- no
- Test type:
- other: different test types used
- Limit test:
- no
Test material
- Reference substance name:
- SS01-SS07_ZnDBM
- IUPAC Name:
- SS01-SS07_ZnDBM
Constituent 1
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified for acute toxicity as per the CLP Regulation EC No.1272/2008
- Conclusions:
- LD50 (m/f) > 2000 mg/kg
- Executive summary:
As no experimental data is available for the potential acute oral toxicity of Zinc, Bis (1,3-Diphenyl-1,3-propanedionate), the acute oral toxicity data reported in literature of read across substances.
Dtsrting from data available from these read-across substances, it is possible to calculate the LD50 value of the test item.
As the threshold for acute oral toxicity classification according to CLP guideline is 2000 mg/kg bw, a comparison between read-across substances and Zn(DBM)2 solubility has been done.
Differences in water solubility of the different read -across substances is one of the parameters that affects GIT absorption. Low water solubility could be associated to the low acute toxicity of this substance.
As Zn(DBM)2 is not soluble in water, it can be assumed that also this substance does not require acute toxicity classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
