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Diss Factsheets
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EC number: 206-466-3 | CAS number: 345-92-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-11 to 2006-03
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions: analytical method no described in enough detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 B (Bioaccumulation: Semi-static Fish Test)
- Version / remarks:
- adopted May 1981
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4,4-Difluoro Benzophenone
- IUPAC Name:
- 4,4-Difluoro Benzophenone
- Details on test material:
- Physical state: white powder
Purity: 99%
Constituent 1
- Radiolabelling:
- no
Sampling and analysis
- Details on sampling:
- - Sampling intervals/frequency for test organisms: at 30 h, 42 h, 72 h, 96 h, 120 h, 144 h, 240 h, 360 h
- Sampling intervals/frequency for test medium samples: at 0 h, 24 h, 48 h, 72 h, 96 h, 120 h, 144 h, 288 h
- Sample storage conditions before analysis: frozen
- Details on sampling and analysis of test organisms and test media samples (e.g. sample preparation, analytical methods):
Test solutions
- Details on preparation of test solutions, spiked fish food or sediment:
- A stock solution with a concentration of 100 mg/mL was prepared in acetone
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- - fish were acclimated to laboratory conditons for 2 weeks
- length: 25 - 35 mm, weight: 0.2 - 0.4 g
Study design
- Route of exposure:
- aqueous
- Test type:
- semi-static
- Water / sediment media type:
- not specified
- Remarks:
- freshwater
- Total exposure / uptake duration:
- 15 d
- Total depuration duration:
- 8 d
Test conditions
- Test temperature:
- 24 +/- 2 °C
- pH:
- 6.95 to 7.04
- Dissolved oxygen:
- 7.9 to 8.1 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- 120 L glass aquaria, filled with 100 L test solution
- Aeration: no:
- Renewal rate of test solution: every 24 hours
- No. of organisms per vessel: 150
- No. of vessels per concentration (replicates): 1 - Nominal and measured concentrations:
- Nominal: 0.1 mg/L and 0.2 mg/L
- Details on estimation of bioconcentration:
- - no data
Results and discussion
Bioaccumulation factoropen allclose all
- Type:
- BCF
- Value:
- 55.4
- Basis:
- whole body w.w.
- Time of plateau:
- 240 h
- Calculation basis:
- steady state
- Remarks on result:
- other: Conc.in environment / dose:0.1 mg/L
- Type:
- BCF
- Value:
- 74.4
- Basis:
- whole body w.w.
- Time of plateau:
- 240 h
- Calculation basis:
- steady state
- Remarks on result:
- other: Conc.in environment / dose:0,2 mg/L
Depuration
- Elimination:
- yes
Any other information on results incl. tables
Concentration (mg/L) |
Cf |
Cw (mg/L, mean value) |
BCF |
0.1 |
5.045 |
0.091 |
55.4 |
0.2 |
12.581 |
0.169 |
74.4 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Executive summary:
The bioaccumulation of 4,4-Difluoro Benzophenone was investigated in a bioaccumulation study with fish according to OECD 305 B. The test species Danio rerio was exposed to the test item at two concentration levels (0.1 and 0.2 mg/L) The uptake phase lasted 15 days (until the steady state was reached) and subsequent elimination was monitored over a period of 8 days. The following steady state BCF values were calculated
Conc. A (0.1 mg/L): BCF = 55.4
Conc. B (0.2 mg/L): BCF = 74.4
The study was assessed as "reliable with restrictions".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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