Registration Dossier
Registration Dossier
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EC number: 200-929-3 | CAS number: 76-05-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only secondary literature
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
- GLP compliance:
- no
- Remarks:
- study performed before GLP establishment
Test material
- Reference substance name:
- Trifluoroacetic acid
- EC Number:
- 200-929-3
- EC Name:
- Trifluoroacetic acid
- Cas Number:
- 76-05-1
- Molecular formula:
- C2HF3O2
- IUPAC Name:
- trifluoroacetic acid
- Details on test material:
- Data from handbook, no specific composition is available.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- no data
- No. of animals per sex per dose:
- 90 rats
- Statistics:
- Method of G.N. Pershin and Lichtfield and Wilcoxon as modified by Rot.
Results and discussion
- Preliminary study:
- no data
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD100
- Effect level:
- 1 000 mg/kg bw
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- 250 mg/kg bw
- Sex:
- not specified
- Dose descriptor:
- other: LD10
- Effect level:
- 500 mg/kg bw
- Clinical signs:
- other: breathing disturbance, motor activity intensified immediately after the administration
- Gross pathology:
- haemorrhaging and necrosis in the mucous membranes of the stomach, dystrophic changes in the liver, kidneys and brain
Any other information on results incl. tables
No other information
Applicant's summary and conclusion
- Executive summary:
Trifluoroacetic acid was administered intragastrically in a single dose in aqueous solution to 90 rats followed by a 14-day observation period.
LD100 = 1000 mg/kg bw
LD10 = 500 mg/kg bw
LD0 = 250 mg/kg
In the clinical picture breathing disturbances similar to those that occur in acute inhalation poisoning are observed. In individual animals the motor activity is intensified immediately after administration of the substance, though more often the animals display less movement and motor activity. Varying degrees haemorrhaging and necrosis in the mucous membranes of the stomach, dystrophic changes in the liver, kidneys and brain were detected in macro and micro-investigations of organ of dead rats.
When the neutralised acids in the form of their salt is administered in a single dose into the stomach, the investigated product were found to be practically non-toxic (experiments carried out by Ye. Ya. Golubovich). A dose of 7000 mg/kg bw was not lethal for the animals, and furthermore no signs of damage to the tissues and organs were detected. It shows that the effects seen with the acid must be only applied to the extrem pH of the substance.
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