Registration Dossier
Registration Dossier
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EC number: 200-929-3 | CAS number: 76-05-1
Endpoint summary
Administrative data
Description of key information
Skin and eye irritation/corrosion: Corrosive
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Additional information
pH is considered as a measure of the potential for inducing harmful effects due to the intensity of alkalinity or acidity (as TFA). However, in addition to the single parameter pH, the quantity of alkali or acid also plays a role. The capacity of a substance to maintain its pH (its buffer capacity) is important in determining biological properties. pH alone does not determine the total acid alkali in a solution. Young et al. (1988; see attached document) demonstrated that the pH-acid/alkali reserve method predicts the classification for irritation and corrosivity.This method generally gives results similar to those obtained from animal test data (Young et al, 1988).
The pH of a trifluoroacetic acid aqueous solution at 10% (w/w) is 0.45 and the measure of the alkali reserve is 35 (as g NaOH/g substance). Following the pH-acid/alkali reserve method, the classification as corrosive is predicted for trifluoroacetic acid.
Hence, in accordance with column 2 of REACH Annex VIII, the in vivo skin irritation study (required in section 8.1.1) and the in vivo eye irritation study (required in section 8.2.1) do not need to be conducted as the substance is a strong acid (pH = 0.45; alkali reserve 35g NaOH/100 g substance, see §4.20).
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Trifluoroacetic acid is classified according to Annex VI of Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008: Trifluoroacetic acid is reported under the Index No 607-091-00-1 and is classified as Skin Corrosion Category 1A (H314, Causes severe skin burns and eye damage). A skin corrosive substance is considered to also cause serious eye damage which is indicated in the hazard statement for skin corrosion (H314: Causes severe skin burns and eye damage). Thus, in this case both classifications (Skin Corr. 1 H314 and Eye Dam. 1 H318) are required, and therefore Eye Dam.1 H318 is added although not reported in the harmonised classification
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