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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

eye irritation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: A degradation category approach is applied, based on the very rapid hydrolysis of boron trichloride. The description and justification of the category is presented in Section 13.
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:

Data source

Reference Type:
other: REACH registration dossier

Materials and methods

Test material

Constituent 1
Reference substance name:
Hydrogen chloride
EC Number:
EC Name:
Hydrogen chloride
Cas Number:
Constituent 2
Reference substance name:
boric acid
boric acid

Results and discussion

In vivo

Irritant / corrosive response data:
HCl applied as an aqueous solution at a percentage of 10 % was classified as “Risk of serious damage to eyes” according to the 83/467/EEC criteria (mean over 24/48/72 hrs of iritis >1.5).
5 % w/w aqueous solution of Hydrochloric acid produced irritation to rabbit eyes.
Boric acid induced mild conjunctivae redness and chemosis and minor effects on the iris. The effects were reversible within 7 days. Therefore, no classification is indicated.

It can be assumed that BCl3 is corrosive to the eye because the degradation product HCl will be produced in a high concentration when BCl3 comes into contact with the water of the eye. This matches the present classification of BCl3 as corrosive.

Applicant's summary and conclusion

Interpretation of results:
highly irritating
Migrated information Criteria used for interpretation of results: OECD GHS
Boron trichloride is highly irritant to the eye.
Executive summary:

Boron trichloride is highly irritant to the eye, which is derived from the actual classification in the CLP regulation and also from the degradation category approach applied, by transcribing the results of hydrochloric acid and boric acid to boron trichloride.

The description and justification of the category approach is presented in Section 13.