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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Endpoint summary

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Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

For in vitro studies, BCl3 has to be included first in the aqueous medium to enable a contact with the cells and then after passing the cell membranes has to be transported in the cytosol to reach the DNA. HCl and also boric acid are released in both cases when BCl3 is coming into contact with the water. Both degradation products are well investigated and were reported to be not genotoxic, neither in vitro nor in vivo. False positive results were only reported in case of significantly lowering of the pH by HCl in in vitro studies.

Relevant information for the 2 degradation products:

Hydrogen chloride:

Hydrochloric acid is not genotoxic in in vitro tests using bacterial or simple eukaryotic cells, while its effects on the pH of the medium precludes the possibility of testing in other in vitro non-bacterial systems. Hydrochloric acid rapidly dissociates almost completely in contact with water, releasing the chloride ion and the hydrogen ion which combines with water to form the hydronium ion. Both chlorine and hydronium ions are normally present in the body, and mammals constantly secrete gastric juices, containing hydrogen ion concentrations equivalent to 0.17 N HCl, into the stomach.

Boric acid:

In vitro gene mutation studies in bacteria and in mammalian cells, and in vitro cytogenicity studies concluded that boric acid is not genotoxic under the conditions of the studies.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Genetic toxicity in vivo

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

All the in vitro data indicate no mutagenic activity.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

No classification is required for boron trichloride regarding genotoxicity as all results on the hydrolysis products were negative in the tests.