Zinc dilactate

Dermal absorption

Administrative data

Endpoint:

dermal absorption in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

Not reported

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Used in risk assessment report for zinc chloride, however the study gives too little details to be used for risk assessment.

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference 1

Reference Type:

publication

Title:

A comparative investigation of the percutaneous absorption of metal compoundsin the guinea pig by means of the radioactive isotopes: 51Cr, 58Co, 65Zn, 110mAg, 115mCd, 203Hg.

Author:

Skog E. and Wahlberg J.E.

Year:

1964

Bibliographic source:

J. Invest. Dermatol. 43, 187-192.

Reference 2

Reference Type:

secondary source

Title:

EU Risk Assessment Report Zinc chloride, Volume 45

Author:

Munn S.J. et al.

Year:

2004

Bibliographic source:

Luxembourg: Office for Official Publications of the European Communities 2004-VIII pp., 116 pp.

Materials and methods

Principles of method if other than guideline:

A percutaneous absorption study was conducted to evaluate the uptake of 65[Zn]-chloride by the dorsal skin of the guinea pig when tested at concentrations ranging from 0.8 to 4.87 M ZnCl2 (pH 1.8-6.1).

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Zinc chloride

EC Number:

231-592-0

EC Name:

Zinc chloride

Cas Number:

7646-85-7

IUPAC Name:

zinc dichloride

Details on test material:

- Name of test material (as cited in study report): Zinc chloride
- Half life: 245 d

Radiolabelling:

yes

Test animals

Species:

guinea pig

Strain:

not specified

Sex:

male/female

Administration / exposure

Type of coverage:

not specified

Vehicle:

water

Duration of exposure:

5 h

Doses:

- Concentrations: 0.8 to 4.87 M (pH 1.8-6.1)
- Rationale for dose selection: The lowest and highest concentration were chosen on account of the specific activity of the isotope and limiting solubility in distilled water at room temperature respectively.
- Replicates: 10 trials at each concentartion

No. of animals per group:

Not reported

Control animals:

no

Results and discussion

Conversion factor human vs. animal skin:

No data

Any other information on results incl. tables

- Disappearance percentage during a 5-hour period was less than 1%, except for the trials with the lowest pH where it was between 1 and 2%.

Applicant's summary and conclusion

Conclusions:

Under the conditions of the test, decline of radioactivity emitted by 65[Zn]-chloride after 5 hours was less than 1% except for the trials with the lowest pH where it might have been between 1 and 2% .

Executive summary:

A percutaneous absorption study was conducted to evaluate the uptake of 65[Zn]-chloride by the dorsal skin of the guinea pig. The decline of radioactivity emitted by 65[Zn]-chloride was monitored in at least 10 trials for each concentration tested ranging from 0.8 to 4.87 M ZnCl2 (pH 1.8-6.1). Under the conditions of the test, decline of radioactivity emitted by 65[Zn]-chloride after 5 hours was less than 1% except for the trials with the lowest pH where it might have been between 1 and 2%.