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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The skin and eye irritation was tested on rabbits in non-GLP studies. Alll tests were perrformed either in accordance with or following the corresponding DOT- and/or  EU-/OECD-test guidelines.
- Skin irritation study (Wallace, 1976): not irritant
- Skin & Eye irritation study (Guillot, 1983): not irritant
The results of the study of 1983 (Guillot) were identified as key values for the the chemical safety assessment.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

The test of 1983 (Guillot) was performed according to OECD- and EU-testing guidelines, therefore it was identified as key study. The second test (Wallace, 1976) was conducted following a comparable test design, before the corresponding test guidelines were available, hence it was identified as supporting study. Both tests were not performed in accordance with GLP, therefore they were considered to have Klimisch 2.

Justification for classification or non-classification

Based on results obtained, and the CLP classification criteria, Valeronitrile is not classified for skin and eye irritation.