Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Short description of key information:
In-vitro assays:
- Ames’ test (OECD TG 471) in S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102 with/without S-9 mix: negative
- Gene mutation (HPRT) in mouse lymphoma cells (OECD TG 476) with/without S-9 mix: negative
- In-vitro micronucleus test (OECD TG 487) in human lymphocytes with/without S-9 mix: positive

In-vivo assay:
- Rat bone marrow micronucleus test (OECD TG 474): negative

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Four reliable tests are available concerning this endpoint: three in-vitro tests and one in-vivo test, covering both gene mutation and chromosome aberration. All the results are negative, except the in-vitro micronucleus test (positive but with a questionable biological relevance).

Based on these data, the test item is considered as non mutagenic. No classification for mutagenicity is required.