2-(propyloxy)ethanol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1981

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Conducted according to generally accepted testing guidelines of the time. Basic data presented only.

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Reference 2

Reference Type:

publication

Title:

Comparative acute and subchronic toxicity of ethylene glycol monopropyl ether and ethylene glycol monopropyl ether acetate

Author:

Katz, G.V., Krasavage, W.J. and Terhaar, C.J.

Year:

1984

Bibliographic source:

Environ. Health Perspect. 57:165-175

Materials and methods

Principles of method if other than guideline:

The study was conducted according to generally recognized procedures of the time. Equivalent to current methods.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-(propyloxy)ethanol

EC Number:

220-548-6

EC Name:

2-(propyloxy)ethanol

Cas Number:

2807-30-9

Molecular formula:

C5H12O2

IUPAC Name:

2-(propyloxy)ethanol

Details on test material:

Test substance name: ethylene glycol monopropyl ether
Specific gravity: 0.913
Purity: >99.1%

Test animals

Species:

rat

Strain:

other: Charles River CD(BR)

Sex:

male

Details on test animals or test system and environmental conditions:

The test species were Charles River COBS, CD, BR male rats (150-200 g). All animals were quarantined and acclimated to the laboratory prior to assignment on the study. Animals were indiviually housed in suspended wire-bottomed cages. Water was available ad libitum. Food was ad libitum except for animals fasted for 16 to 20 hours prior to treatment.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

Administered undiluted using a glass syringe fitted with a polypropylene catheter.

Doses:

Ranged from 2.6 to 168 mM/kg bw

No. of animals per sex per dose:

5 in 5 dose groups

Control animals:

yes

Details on study design:

The acute oral LD50 values of test material were determined in separate groups of fasted and fed animals (150-200 g). Groups of 5 animals were given various doses of undiluted test material by gavage. Doses given were calculated on a mM/kg basis, and progressed by a factor of two (individual doses given were not listed). General appearance and activity, pharmacologic and toxicologic signs and mortality were checked twice daily (except on weekends and holidays).

The appearance of stools and urine was noted. Individual body weights were recorded prior to testing and at the end of the 2-week observation period. Animals that died and all survivors were necropsied and examined for gross pathology.

Statistics:

The LD50 value with its 95% confidence interval was calculated using the method of Thompson and Weil.

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LD50

Effect level:

3 089 mg/kg bw

Based on:

test mat.

95% CL:

2 340 - 4 077

Remarks on result:

other: Fasted rats. LD50: 29.70 (22.5- 39.2) mM/kg

Effect levels 2

Sex:

male

Dose descriptor:

LD50

Effect level:

6 178 mg/kg bw

Based on:

test mat.

95% CL:

4 680 - 8 154

Remarks on result:

other: Fed rats. LD50: 59.40 (45.0-78.4) mM/kg

Mortality:

Number of deaths at each dose not given.

Clinical signs:

other: Clinical signs of toxicity for both fed and fasted animals (numbers of animals affected were not stated) were inactivity, labored breathing, rapid respiration, anorexia, slight to moderate weakness, tremors, prostration and death. Animals that died exhibi

Gross pathology:

All survivors were necropsied and examined for gross pathology.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Remarks:

Migrated information

Conclusions:

The LD50 value in fasted rats (and its confidence interval) was 29.70 (22.5-39.2) mM/kg, or 3089 (2340-4077) mg/kg. The LD50 value in fed rats (and its confidence interval) was 59.40 (45.0-78.4) mM/kg, or 6178 (4680-8154) mg/kg. The majority of deaths occurred within the first 3 days. The number of deaths at each dose was not stated.