Didecyldimethylammonium chloride

Stability in organic solvents and identity of relevant degradation products

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

stability in organic solvents and identity of relevant degradation products

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From July 18, 2011 to April 24, 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Qualifier:

according to guideline

Guideline:

other: CIPAC, Analysis of technical and formulated Pesticides, MT 46.3 “Accelerated Storage Procedure”, CIPAC Handbook Volume J, 2000.

Deviations:

no

GLP compliance:

yes

Test substance stable:

yes

Transformation products:

not specified

Results

After storage, DDAC content was determined in all samples within 24 hours after removing the bottle and vial from the oven. The concentration analysed in the vial stored at 54°C was comparable with the concentration analysed in the bottle stored at ambient temperature.

The DDAC content had not decreased by more than 5% during storage at 54 ± 2°C and is therefore considered stable during this storage which is equivalent to storage for 2 years at ambient conditions. The concentration analysed in the bottle stored at 54°C had increased significantly due to evaporation of isopropanol.

Storage	Analysed DDAC Concentration (mg/L)	Analysed DDAC concentration relative to the analysed DDAC concentration after storage at ambient temperature (%)
Ambient temperature	74.6
-80 °C	76.8	103
54°C (bottle)	87.3	117*
54°C (vial)	77.4	104

(*): higher value due to evaporation

Conclusions:

Under the study conditions, the test substance content was not found to be decreased by more than 5% during storage at 54 ± 2°C. Hence, it is considered to be stable for 2 years at ambient conditions.

Executive summary:

A study was conducted to determine the stability of DDAC in isopropanol according to the CIPAC method (MT 43.6). DDAC was incubated in a bottle and an air tight vial and content was determined in both the samples within 24 hours after removing the bottle and vial from the oven. The concentration analysed in the vial stored at 54°C was comparable with the concentration analysed in the bottle stored at ambient temperature. Under the study conditions, the test substance content was not found to be decreased by more than 5% during storage at 54 ± 2°C. Hence, it is considered to be stable in isopropanol for 2 years at ambient conditions.

Reference 2

Endpoint:

stability in organic solvents and identity of relevant degradation products

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2007

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: OECD Guideline 105

GLP compliance:

yes (incl. QA statement)

Test substance stable:

yes

Transformation products:

no

Following OECD Guideline 105 for Testing of Chemicals (1995). 100 g of the test item were weighed in a bottle with a gas tight sealing. 100 g of 2-Propanol was added and the mixture was shaken with a rotary shaker for 24 hours. Afterwards the mixture was filtered with a folded filter and the concentration of the test item in the solution was determined by LC-MS/MS.

Conclusions:

The active substance DDAC is stable in 2-propanol at 50 °C over a period of 120 hours

Executive summary:

The active substance DDAC is stable in 2-propanol at 50 °C over a period of 120 hours.

Description of key information

The stability of the test substance in 2-propanol (isopropanol) was determined according to OECD Guideline 105 (Lange, 2007) and CIPAC Method 43.6 (Brekelmans, 2012).

Additional information

The substance is stable in 2-propanol (isopropanol) for 120 h at 50°C for 2 years under ambient conditions.