2-(2-hexyloxyethoxy)ethanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1987

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

Purity of the test material was not listed. Concentration of material in the atmosphere was not analyzed.

Data source

Reference

Reference Type:

publication

Title:

The comparative acute toxicity|and primary irritancy of the monohexyl ethers of ethylene|and diethylene glycol.

Author:

Ballantyne B,; Myers R. C.

Year:

1987

Bibliographic source:

Vet Human Tox 29:361-366

Materials and methods

Principles of method if other than guideline:

Five rats of each sex weighing between 200 and 300g were exposed to a statically generated saturated vapour for 6 hours.

GLP compliance:

no

Test type:

fixed concentration procedure

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-(2-hexyloxyethoxy)ethanol

EC Number:

203-988-3

EC Name:

2-(2-hexyloxyethoxy)ethanol

Cas Number:

112-59-4

Molecular formula:

C10H22O3

IUPAC Name:

2-[2-(hexyloxy)ethoxy]ethan-1-ol

Test material form:

liquid

Specific details on test material used for the study:

- Name of test material (as cited in study report): diethylene glycol monohexyl ether (DGHE)
- Physical state: Colorless liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

The animals were maintained on appropriate commercial diet and municipal water. Both were available adlibitum except during exposure period.

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

not specified

Details on inhalation exposure:

Five rats of each sex weighing between 200 and 300g were exposed to a statically generated saturated vapour for 6 hours. The vapour was produced by enclosing the test material into a sealed 120 liter animal chamber and allowing the vapour to equilibrate for 18 hours (Static condition). Rats were introduced into separate chambers through gasketted drawers designed to minimize vapour loss. Oxygen content was continuously monitored and maintained at 20%. Animals were removed from the chamber after 6 hours of exposure and were observed for 14 days. Body weights were measured before exposure and 7 and 14 days following exposure. All rats were subjected to necropsy after the 14 day observation period.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

6 h

Concentrations:

Substantially Saturated vapour (Static)

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

The animals were maintained on appropriate commercial diet and municipal water. Both were available adlibitum except during exposure period.
Five rats of each sex weighing between 200 and 300g were exposed to a statically generated saturated vapour for 6 hours. The vapour was produced by enclosing the test material into a sealed 120 liter animal chamber and allowing the vapour to equilibrate for 18 hours (Static condition). Rats were introduced into separate chambers through gasketted drawers designed to minimize vapour loss. Oxygen content was continuously monitored and maintained at 20%. Animals were removed from the chamber after 6 hours of exposure and were observed for 14 days. Body weights were measured before exposure and 7 and 14 days following exposure. All rats were subjected to necropsy after the 14 day observation period.

Statistics:

Not applied

Results and discussion

Preliminary study:

No data available

Effect levels

Key result

Sex:

male/female

Based on:

test mat.

Exp. duration:

6 h

Remarks on result:

other: Substantial Saturated Vapours-Concentration Unknown

Remarks:

No mortality occurred

Mortality:

None. All animals survived the 6 hour exposure.

Clinical signs:

other: There were no signs of toxicity or irritancy during or after exposure.

Body weight:

Body weight gain was observed across the treatment groups.

Gross pathology:

None

Other findings:

None

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

No signs of inhalation toxicity were observed when rats were exposed to substantially saturated vapours for 6 hours.

Executive summary:

Five rats of each sex weighing between 200 and 300g were exposed to a statically generated saturated vapour for 6 hours. The vapour was produced by enclosing the test material into a sealed 120 liter animal chamber and allowing the vapour to equilibrate for 18 hours (Static condition). Rats were introduced into separate chambers through gasketted drawers designed to minimize vapour loss. Oxygen content was continuously monitored and maintained at 20%. Animals were removed from the chamber after 6 hours of exposure and were observed for 14 days. Body weights were measured before exposure and 7 and 14 days following exposure. All rats were subjected to necropsy after the 14 day observation period. All animals survived the 6 hour exposure. There were no signs of toxicity or irritancy during or after exposure. Animals gained weight over the fourteen day observation period and had normal pathology.