Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 272-944-3 | CAS number: 68921-52-8
Endpoint summary
Administrative data
Description of key information
Additional information
Three studies on ready biodegradation are available for the PFAE fumarates category (i.e. Didodecyl fumarate CAS 2402-58-6, MW 453 g/mol, Ditetradecyl fumarate CAS 10341-03-4, MW 509 g/mol and 2-Butenedioic acid (E)-, di-C18-22-alkyl esters CAS 68921-53-9, MW 621-733 g/mol). In all tests the pass level for ready biodegradation was reached in 28 days. The strict criterion of the 10 day window however was not fulfilled for Didodecyl fumarate CAS 2402-58-6 and Ditetradecyl fumarate CAS 10341-03-4 (both monoconstituent substances). These substances are therefore regarded as readily biodegradable, but failing 10 day window. For 2-Butenedioic acid (E)-, di-C18-22-alkyl esters CAS 68921-53-9 the 10 day window is however not applicable, since this substance is a UVCB. This substance is therefore regarded as ready biodegradable. Based on a weight of evidence approach the remaining three members of the category (namely: 2-Butenedioic acid (E)-, di-C8-18-alkyl esters CAS 68610-90-2, MW 341-621 g/mol, 2-Butenedioic acid (E)-, di-C12-18-alkyl esters CAS 68921-51-7, MW 453-621 g/mol and 2-Butenedioic acid (E)-, di-C16-18-alkyl esters CAS 68921-52-8, MW 565-621 g/mol) were assessed regarding their biodegradability using the studies mentioned above. As the pass level was reached in all tests and due to the variable composition of the remaining category members, these substances were assessed as readily biodegradable.
For two substances, namely Ditetradecyl fumarate (CAS 10341-03-4) and 2-Butenedioic acid (E)-, di-C18-22-alkyl esters (CAS 68921-53-9) OECD 301B tests were enhanced up to 60 days, resulting in high overall degradation rates for both (87- 90% after 60 d).
CAS |
Substance name |
% degradation after 28 days |
% degradation after 60 days |
Biodegradation asssessment |
2402-58-6 |
Didodecyl fumarate |
67% (BODIS test) |
-- |
readily, but failing 10 day window |
10341-03-4 |
Ditetradecyl fumarate |
71% (OECD 301B) |
90% (OECD 301B) |
readily, but failing 10 day window |
68610-90-2 |
2-Butenedioic acid (E)-, di-C8-18-alkyl esters |
RA: CAS 2402-58-6 RA: CAS 10341-03-4 RA CAS 68921-53-9 |
-- |
readily biodegradable |
68921-51-7 |
2-Butenedioic acid (E)-, di-C12-18-alkyl esters |
RA: CAS 2402-58-6 RA: CAS 10341-03-4 RA CAS 68921-53-9 |
-- |
readily biodegradable |
68921-52-8 |
2-Butenedioic acid (E)-, di-C16-18-alkyl esters |
RA: CAS 2402-58-6 RA: CAS 10341-03-4 RA CAS 68921-53-9 |
-- |
readily biodegradable |
68921-53-9 |
2-Butenedioic acid (E)-, di-C18-22-alkyl esters |
62% (OECD 301B) |
87% (OECD 301B) |
readily biodegradable |
The available studies cover the outer borders of this category so that this endpoint is covered by interpolation (i.e. studies are available for the lower alcohol chain length (C12, C14) and highest alcohol chain length (C18/C22), respectively). Only two constituents, i.e. C8 and C10 fatty acid ester components of 2-Butenedioic acid (E)-, di-C8-18-alkyl esters (CAS 68610-90-2) are outside of the category. However, since the C-chain length is a determining factor in biodegradation, the biodegradability for these two components is even expected to be faster compared to higher chain lengths fumarates. 2-Butenedioic acid (E)-, di-C18-22-alkyl esters (CAS 68921-53-9) represents the higher end of the category consisting of the longest fatty alcohol chain lengths and therefore represents a worst case for biodegradation since as mentioned above, the C-chain length of the fatty alcohol is the determining factor for biodegradation. Thus, the assumption that all members of the PFAE fumarates category are either readily biodegradable (in case of UVCBs) or readily biodegradable, but failing 10-day window (in case of monoconstituent substances) is clearly underlined by the result for this substance (readily biodegradable). The substances are thus expected to be rapidly degraded by microorganisms in both the aquatic and terrestrial environment, therefore in accordance with Regulation (EC) No. 1907/2006, 9.2.1.2 – 9.2.1.4, further simulation testing for water and sediment or soil biodegradation are not necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
