Registration Dossier
Registration Dossier
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EC number: 204-552-5 | CAS number: 122-52-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS (publicly available peer reviewed source). Original document not available.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report For SIAM 16 (Triethyl Phosphite), 2003 Paris.
- Author:
- OECD
- Year:
- 2 003
- Bibliographic source:
- UNEP Publications
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- no
- GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- Triethyl phosphite
- EC Number:
- 204-552-5
- EC Name:
- Triethyl phosphite
- Cas Number:
- 122-52-1
- Molecular formula:
- C6H15O3P
- IUPAC Name:
- triethyl phosphite
- Details on test material:
- Purity: 98.8%
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Bor:DHPW guinea pigs
- Sex:
- not specified
- Details on test animals and environmental conditions:
- Mean weight: 327 g.
Age: 5-7 weeks.
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- peanut oil
- Concentration / amount:
- 1st: Induction 5 % intracutaneous
2nd: Induction 100 % occlusive epicutaneous
3rd: Challenge 100 % occlusive epicutaneous
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- peanut oil
- Concentration / amount:
- 1st: Induction 5 % intracutaneous
2nd: Induction 100 % occlusive epicutaneous
3rd: Challenge 100 % occlusive epicutaneous
- No. of animals per dose:
- 50 animals (no further details)
- Details on study design:
- RANGE FINDING TESTS:
Test concentrations for the main study were determined from the results of a pre-study on the irritation threshold, performed with 50 male animals.
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 1 intradermal, 1 epicutaneous
- Concentrations: 5% intradermal, 100% (epicutaneous)
B. CHALLENGE EXPOSURE
- No. of exposures: 1 epicutaneous
- Concentrations: 100% - Challenge controls:
- No data.
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 100%
- No. with + reactions:
- 19
- Total no. in group:
- 20
- Remarks on result:
- other: . Hours after challenge: 48.0. Group: test group. Dose level: 100%. No with. + reactions: 19.0. Total no. in groups: 20.0.
- Hours after challenge:
- 48
- Group:
- negative control
- No. with + reactions:
- 0
- Remarks on result:
- other: . Hours after challenge: 48.0. Group: negative control. No with. + reactions: 0.0.
Any other information on results incl. tables
19 out of 20 animals showed positive results at 48 hours after challenge with the undiluted test material. None of the negative control animals showed any positive effects.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
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