Registration Dossier
Registration Dossier
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EC number: 604-958-6 | CAS number: 15448-47-2
Carcinogenicity
Administrative data
Description of key information
Inhalation studies in animals have shown that propylene oxide produces a spectrum of upper respiratory tract changes, from inflammation and degeneration to metaplasia and neoplasia. Repeated oral administration by gavage in rats induced carcinoma in the epithelium of the forestomach.
It is evident that carcinogenic responses to propylene oxide are primarily confined to the sites of initial contact. Due to its direct-acting nature and its mutagenic activity, the carcinogenic hazard of propylene oxide expressed in animals is considered relevant to humans. In view of the potential genotoxic contribution to the carcinogenic mechanism of propylene oxide, it is not possible to establish an exposure level at which there would be no increased risk of carcinogenicity.
Classification according to Annex I of Directive 67/548/EC is proposed as follows: Carc. Cat. 2; R45 May Cause Cancer.
Key value for chemical safety assessment
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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