Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 231-728-9 | CAS number: 7705-07-9
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and suitable for read-across.
Data source
Reference
- Reference Type:
- publication
- Title:
- Titanium tetrachloride burns to the eye
- Author:
- Chitkara DK, McNeela BJ
- Year:
- 1 992
- Bibliographic source:
- British Journal of Ophthalmology 76: 380-382
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- eye irritation
- Principles of method if other than guideline:
- Eight cases of chemical burns of the eyes from titanium tetrachloride are presented.
- GLP compliance:
- no
- Remarks:
- not applicable
Test material
- Reference substance name:
- 7750-45-0
- Cas Number:
- 7750-45-0
- IUPAC Name:
- 7750-45-0
- Details on test material:
- - Name of test material (as cited in study report): Titanium tetrachloride
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 8
- Sex: All male
- Age: 19 - 46 years old
- Race: unknown - Ethical approval:
- not applicable
- Route of exposure:
- ocular
- Reason of exposure:
- accidental
- Details on exposure:
- All eight patients were accidentally exposed to titanium tetrachloride splashes. The exposure occured on various parts of the body, mainly face, eyes, and skin.
Results and discussion
- Clinical signs:
- The severity of the clinical signs was dependent on the exposure. The following observations were made on some of the workers: Hypopyon, glaucoma, entropion, trichiasis, corneal scarring and vascularisation, enucleation, cataracis, corneal perforation, corneal neovascularisation, symblepharon, pseudoterygium, and pulmonary oedema.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
