Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented. Data is suitable for read-across.

Data source

Reference
Reference Type:
publication
Title:
Studies on the design of animal tests for the corrosiveness of industrial chemicals
Author:
Potokar M, Grundler OJ, Heusener A, Jung R, Mürmann P, Schöbel C, Suberg H, Zechel HJ
Year:
1985
Bibliographic source:
Fd. Chem. Toxic. 23(6): 615-617

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Version / remarks:
(adopted 2002)
Deviations:
yes
Remarks:
(6 animals were tested, local reactions were examined after 1 and 4 h, occlusive and semi-occlusive dressing was used)
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Titanium tetrachloride
EC Number:
231-441-9
EC Name:
Titanium tetrachloride
Cas Number:
7550-45-0
IUPAC Name:
titanium tetrachloride
Details on test material:
- Name of test material (as cited in study report): Titanium tetrachloride
- Analytical purity: No data

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Various breeders, not specified
- Weight at study initiation: 2-4 kg
- Housing: Individually
- Diet: Ad libitum (except during exposure), standard rabbit feed
- Water: Ad libitum (except during exposure)


ENVIRONMENTAL CONDITIONS
Standardised laboratory conditions, no further data

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin of the same animals
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
Duration of treatment / exposure:
1 and 4 hours
Observation period:
7 days
Number of animals:
6 for each exposure time
Details on study design:
TEST SITE
- Area of exposure: Dorsal and lateral parts of the trunk
- % coverage: Unspecified, gauze pads with 3x3 cm were used
- Type of wrap if used: Air permeable circular bandage


REMOVAL OF TEST SUBSTANCE
- Washing (if done): Rinsed with water and dried
- Time after start of exposure: Either after 1 or 4 hours


SCORING SYSTEM: As described in the OECD guideline 404

Results and discussion

In vivo

Results
Irritation parameter:
other: full thickness destruction
Basis:
mean
Remarks:
out of all 6 animals
Time point:
other: 1 h
Reversibility:
not reversible
Remarks on result:
other: Score n.a.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information