2-(phenylmethoxy)naphthalene

Genetic toxicity: in vivo

Administrative data

Endpoint:

in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus

Remarks:

Type of genotoxicity: chromosome aberration

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: reference study data from SNIF file

Data source

Reference

Reference 1

Reference Type:

other: SNIF data provided by ECHA

Title:

Unnamed

Report date:

1990

Reference 2

Reference Type:

secondary source

Title:

Unnamed

Year:

1990

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)

GLP compliance:

yes

Type of assay:

micronucleus assay

Test material

Test material information

Constituent 1

Reference substance name:

2-(phenylmethoxy)naphthalene

EC Number:

405-490-3

EC Name:

2-(phenylmethoxy)naphthalene

Cas Number:

613-62-7

Molecular formula:

C17 H14 O

IUPAC Name:

2-(benzyloxy)naphthalene

Test animals

Species:

mouse

Strain:

NMRI

Sex:

male/female

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

corn oil

Duration of treatment / exposure:

animals given 200, 670 or 2000 mg/kg bw ( 5 males and 5 females in each group): 24 h
5 males and 5 females given 2000 mg/kg bw: 48 h

Frequency of treatment:

once

Post exposure period:

24/ 48 h

Doses / concentrations

Remarks:

Doses / Concentrations:
0, 200, 670 or 2000 mg/kg bw
Basis:
no data

No. of animals per sex per dose:

5 (200, 670 mg/kg bw)
10 (2000 mg/kg bw)

Control animals:

yes, concurrent vehicle

Positive control(s):

30 mg/kg of cyclophosphamide

Examinations

Tissues and cell types examined:

Bone marrow smears were made from each animal and 1000 polychromatic erythrocytes were scored for micronuclei.

Results and discussion

Test results

Sex:

male/female

Genotoxicity:

negative

Toxicity:

no effects

Remarks:

however in a preliminary toxicity study, signs of toxicity occurring at 2000 mg/kg/d included reduction of spontaneous activity, eyelid closure and apathy for up to 6 hours following treatment

Vehicle controls validity:

valid

Negative controls validity:

not specified

Positive controls validity:

valid

Additional information on results:

No cytotoxicity was reported in any treatment or control assays. No significant increase in the number of micronucleated polychromatic erythrocytes was reported in treatment assays. The positive control induced micronuclei as expected.