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EC number: 215-304-0 | CAS number: 1320-51-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
We have no specific data on the absorption, distribution, metabolism and excretion of Hydroxyethyl urea CAS No 1320-51-0. We do have data from a series of predictive tools.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
We have no specific data on the absorption, distribution, metabolism and excretion of Hydroxyethyl urea CAS No 1320-51-0.
Molecular chemical profile and estimated properties: There is an alternative CAS No 2078-71-9 and structure Urea, (2-hydroxyethyl) - model data for both is presented below.
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Absorption
Hydroxyethyl urea would be expected to be rapidly absorbed from the gastrointestinal tract; the modelling (Epiwin) information predicts ca. 77%. It would be assumed to be readily absorbed in the lungs, although this is highly unlikely route of exposure. It is also expected to be absorbed through the skin, the Epiwin model data below predicts 78.3% can reach the viable epidermis and therefore be available for absorption. See the attached file for the diagram.
Metabolism
DEREK and the OECD tool box are not able to predict the metabolites of hydroxyethyl urea. This substance is readily biodegradable; therefore it would be expected to be rapidly metabolized in the body. This might be expected to results in CO2, water and urea.
Excretion
The urine would be expected to be the main route of excretion for the urea and water with the CO2being exhaled.
References:
Molecular formula, molecular weight, pKa and logD were all calculated using ChemAxon MarvinSketch (v.5.4.0.1).
Melting point, boiling point, vapour pressure and logPow were estimated by EPI Suite (v4.1).
Solubility and logPow are estimated using ALOGPS 2.1 (VCCLAB, Virtual Computational Chemistry Laboratory,http://www.vcclab.org, 2005)
Reactivity: QSAR Toolbox v.3.0: profiling: DNA binding (OASIS v1.1; OECD); Protein binding (OASIS v1.1; OECD)
HOMO/LUMO Energy, [eV], and the quantum-chemical descriptor (the energy of the highest occupied resp. lowest unoccupied molecular orbital), are calculated in OASIS software, based on MOPAC 7.
(a large difference between HOMO and LUMO energies implies high stability and thus low reactivity)
Absorption properties:
- dermal: EpiSuite v. 4.1; intestinal (water:0.0005 cm/hr): (Pow based on ALOGPS 2.1)
- HIA: QSAR toolbox (version 3.1) (Human Intestinal Absorption)
Max. dermal absorption: IH Skin Perm v1.03 from AIHA (applying estimated data; density assumed 1)
EpiWin does not know CAS number 2078-71-9, and for CAS 1320-51-0 provides the structure with the terminal hydroxyl. Results for EpiWin in the table above are based on the structures.
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