α-[(benzyl-tert-butylamino)methyl]-m-xylene-4,α,α'-triol

Guidance on Safe Use

First-aid measures

Ingestion:

Never attempt to induce vomiting. Do not attempt to give any solid or liquid by mouth if the

exposed subject is unconscious or semi-conscious. Wash out the mouth with water. If the

exposed subject is fully conscious, give plenty of water to drink. Obtain medical attention.

Inhalation:

Using appropriate personal protective equipment, move exposed subject to fresh air. If breathing

is difficult or ceases, ensure and maintain ventilation. Give oxygen as appropriate. The exposed

subject should be kept warm and at rest. Obtain medical attention in cases of known or possible

over exposure, or with symptoms including chest pain, difficulty breathing, loss of consciousness

or other adverse effects, which may be delayed.

Skin contact:

Using appropriate personal protective equipment, remove contaminated clothing and flush

exposed area with large amounts of water. Obtain medical attention if skin reaction occurs, which

may be immediate or delayed.

Eye contact:

Wash immediately with clean and gently flowing water. Continue for at least 15 minutes. Obtain

medical attention.

Fire-fighting measures

Fire and explosion hazards:

This material is non-combustible.

Dust clouds are potentially extremely sensitive to ignition from incendive electrostatic discharges.

Dust clouds are of very low sensitivity to ignition from hot surfaces.

No ignition or exotherm of a powder layer observed up to 400 °C.

Ignition of a dust cloud produces a very strong dust explosion.

High pressure between 8 and 10 bar is produced during a dust explosion.

Suitable extinguishing media: No special requirements needed. Water is recommended for fires involving packaging.

Special protective Equipment and precautions for firefighters:

Since toxic, corrosive or flammable vapours might be evolved from fires involving this material,

self contained breathin

g apparatus and full protective equipment are recommended for firefiMove containers from the fire area if possible without increased personal risk.

If possible, contain and collect firefighting water for later disposal.

Specific hazards arising form the material:

Toxic or corrosive thermal decomposition products are expected when this material is exposed to

fire.

Accidental release measures

Personal Precautions: Fence or cordon the affected area and do not allow individuals to touch or walk through the spilled

material unless wearing appropriate protective clothing. Avoid dust generation.

Environmental Precautions:

Prevent entry into waterways, sewers, surface drainage systems and poorly ventilated areas. If

spill is outdoors, cover with plastic sheet to minimise spreading or contact with rain.

Decontamination Procedures: Non-hazardous solvents specified in Section 9, under solubility, or detergent solutions can be

used for clean-up and decontamination operations.

Handling and storage

General requirements:

Depending upon the scale of operation, use of appropriate exhaust ventilation is recommended to

provide routine control of fire and explosion hazards during handling of this material.

Ignition Controls:

Bond and earth (ground) all plant and equipment to ensure that no isolated conductors are

present. Isolated conductors can accumulate sufficient electrostatic charge to produce discharges

of many hundreds of milli-Joules.

Consider earthing (grounding) personnel dealing with dusty operations. An isolated (insulated)

human body can readily produce electrostatic discharges in excess of 50 mJ, but have been

recorded up to 100 mJ.

Minimise the use of plastics when handling this material. Handle and store this material only in

conductive or anti-static plastic liners (bags) since normal plastics are known to be capable of

producing electrostatic discharges of up to 4 mJ, ensuring that any containers into which they are

placed are themselves of a conductive material and earthed (grounded).

Due to the very low minimum ignition energy for this powder, it is advisable to treat this material

as if it is a flammable solvent vapour.

The maximum surface temperature of enclosures potentially exposed to this material should be

the lower of the values obtained by taking 2/3 of the minimum ignition temperature for a dust

cloud or 75 K less than the minimum ignition temperature of the dust layer, with a maximum

temperature of 325 °C.

Protective Systems

Assess operations based upon available dust explosion information to determine the suitability of

preventive or protective systems as precautionary measures against possible dust explosions. If

prevention is not possible, consider protection by use of containment, venting or suppression of

dust handling equipment. Where explosion venting is considered the most appropriate method of

protection, vent areas should preferably be calculated based on the Kst rather than the St value.

If nitrogen purging is considered as the protective system, it must operate with an oxygen level

below the limiting oxygen concentration.  The system should include an oxygen monitoring and

shut-down facility in the event of excessive oxygen being detected.

At both ambient and low humidity, this material is of low conductivity.  Generation of electrostatic

charge is considered likely to occur even when handled in an earthed (grounded) environment.

At both ambient and low humidity, this material has an extremely long charge relaxation time.

Accumulation of electrostatic charge will occur even when handled in an earthed (grounded)

environment. Under these conditions, it is considered that this material might present a very high

risk of producing an electrostatic discharge

Conditions for safe storage

Keep in tightly closed containers or packages away from moisture and away from sources of

ignition.

Avoid prolonged storage at elevated temperatures (greater than room temperature, approximately

20 degrees C).

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

UN 3077

Shipping information

Proper shipping name and description:

Environmentally hazardous substance, solid, nos

Chemical name:

(BENZYL;BENZYL)

Remarks

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

Engineering Controls:

This material has been assigned to GlaxoSmithKline Occupational Hazard Category 3 with a

hygiene guide of 10 - <100 mcg/m3. An Exposure Control Approach (ECA) is established for

operations involving this material based upon the OEL/Occupational Hazard Category and the

outcome of a site- or operation-specific risk assessment. Refer to the Exposure Control Matrix for

more information about how ECA's are assigned and how to interpret them.

Containment

Open handling is not recommended. Consider segregating operations, use of enclosures and

sealed transfer systems.

Ventilation:

Local exhaust ventilation (LEV) should be used in conjunction with other control measures as a

means of removing material incidentally released.

Adminsitrative:

Entry to the working area should be controlled. Doors with interlocks may be needed for materials

airlocks and locker rooms. Only equipment and supplies necessary for job activities should be

taken into working area.

Personal Protective Equipment:

Eye Protection:

ear approved safety glasses with side shields or cover goggles if eye contact is possible.

Gloves:

The selection of gloves for a specific activity must be based on the material's properties and on

possible permeation and degradation that may occur under the circumstances of use. Glove

selection must take into account any solvents and other hazards present. Potential allergic

reactions can occur with certain glove materials (e.g. Latex) and therefore these should be

avoided. Care must be exercised if insufficient data are available and further guidance should be

sought from your local EHS department.

Respirators:

If respiratory protective equipment (RPE) is used, the type of RPE will depend upon air

concentrations present, required protection factor as well as hazards, physical properties and

warning properties of substances present. Follow local regulations for respirator use in the

workplace.

An eye wash station should be available. Consider control procedures for maintenance, cleaning

and emergencies.

Stability and reactivity

Conditions to Avoid

Avoid direct sunlight, conditions that might generate heat and dispersion as a dust cloud.

Disposal considerations

Collect for recycling or recovery if possible. The recommended method of disposal is incineration.

Wherever possible, disposal should be in an on-site licenced chemical incinerator, if allowed by

the incinerator licence or permit.  If no on-site incinerator is available, dispose of material in a

licenced commercial chemical incinerator.

Observe all local and national regulations when disposing of this material.