Registration Dossier
Registration Dossier
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EC number: 406-040-9 | CAS number: 125643-61-0
Endpoint summary
Administrative data
Description of key information
Additional information
The registrant has undertaken an assessment of bioaccumulation potential, as the value for partition coefficient is not considered to be reflective of the potential for the substance to bioaccumulate in this case, and testing of this poorly soluble UVCB substance for the bioaccumulation endpoint is not considered relevant. The substance has been demonstrated to have a very high partition coefficient value. However, the high log Pow is considered to be more a consequence of poor water solubility issues than a lipophilic tendency and is considered to be not indicative of the tendency to bioaccumulate in lipid tissues of aquatic organisms. This is based on literature data which demonstrates a tendency for the Bioconcentration Factor (BCF) to decrease as Log Pow increases above 6. At a high value of 10, the substance is proposed not to bioaccumulate. This is further confirmed via the use of QSAR; use of the US EPA BCFBAF v3.01 programme for bioaccumulation indicates that the substance is unlikely to bioaccumulate, with calculated values used for the assessment of 6 different potential structures for C7, C8 and C9 componentsC7, C8 and C9 components as follows:
|
BCF value (L/kg wet-wt) |
Log BCF value |
Typical % w/w |
||||
C7 derivatives |
648.4 - 5704 |
2.812 – 3.756 |
9.0 |
||||
C8 derivatives |
372.6 - 1887 |
2.571 – 3.276 |
>76.0 |
||||
C9 derivatives |
123 - 1178 |
2.090 – 3.071 |
15.0 |
Given the fact that the substance is subject to hydrolysis at biologically relevant pH’s (4 and 9), it is anticipated that bioaccumulation of the substance itself would not occur, as hydrolytic effects in association with metabolic effects would result in removal of the substance. In addition, the majority of the substance does not fall into a BCF range where classification is applicable. These factors indicate that bioaccumulation within body tissues is unlikely.
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