Registration Dossier
Registration Dossier
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EC number: 203-526-0 | CAS number: 107-85-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
There are no experimental results for 3-methylbutylamine itself known to exist. However, structurally related primary alkylamines e.g. cyclohexylamine, hexylamine, n-octylamine, isopropylamine, 2-aminobutane) failed to produce an allergic response in screening test (e.g. mouse-ear swelling test) (Bingham et al. 2000). Also, N-Butylamine is reported to have been negative in a study of the potential of skin sensitisation (no primary source cited; Greim et al. 1998). 3-methylbutylamine is therefore not considered to have a skin sensitising activity.
3-methylbutylamine is considered to be corrosive to the skin, and therefore skin sensitisation testing is not allowed according to REACH, Annexes VII and VIII, section 8.1, column 2. Skin protection is required to protect against skin corrosion and irritation, and this will also protect against sensitisation in the unlikely case that the substance should possess a weak sensitisation potential.
Migrated from Short description of key information:
3-methylbutylamine is not considered to be a skin sensitiser. It is corrosive to the skin. Skin protection is therefore required.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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