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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: OECD method, GLP compliance

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD GUIDELINE 471 (84/449/EEC B.13 AND B.14)
GLP compliance:
yes
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(4,6-diphenyl-1,3,5-triazin-2-yl)-5-((hexyl)oxy)phenol
EC Number:
411-380-6
EC Name:
2-(4,6-diphenyl-1,3,5-triazin-2-yl)-5-((hexyl)oxy)phenol
Cas Number:
147315-50-2
Molecular formula:
C27H27N3O2
IUPAC Name:
2-(4,6-diphenyl-1,3,5-triazin-2-yl)-5-(hexyloxy)phenol

Method

Species / strain
Species / strain / cell type:
bacteria, other: SALMONELLA TYPHIRIUM TA 98,TA 100, TA 1535, TA 1537 ESCHERICHIA COLI WP2uvrA
Metabolic activation system:
RAT LIVER MICROSOMAL FRACTION (S9 MIX)
Test concentrations with justification for top dose:
Concentration range in the main test (with metabolic activation):321...5000 μg/plate
Concentration range in the main test (without metabolic activation):321...5000 μg/plate
Vehicle / solvent:
Solvent: DMSO (50 mg
Details on test system and experimental conditions:
Concentration of the test substance resulting in precipitation: 5000 μg/plate

Results and discussion

Test resultsopen allclose all
Species / strain:
other: as specified above
Metabolic activation:
with
Genotoxicity:
other: not provided by inquiry
Cytotoxicity / choice of top concentrations:
cytotoxicity
Remarks:
(> 5000 μg/plate)
Species / strain:
other: as specified above
Metabolic activation:
without
Genotoxicity:
other: not provided by inquiry
Cytotoxicity / choice of top concentrations:
cytotoxicity
Remarks:
(> 5000 μg/plate)
Additional information on results:
Observations:
NO EVIDENCE OF INDUCTION OF POINT MUTATIONS IN PRESENCE OR ABSENCE OF METABOLIC ACTIVATION
Remarks on result:
other: other: preliminary test
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation