Registration Dossier
Registration Dossier
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EC number: 202-443-7 | CAS number: 95-71-6
Endpoint summary
Administrative data
Description of key information
A secondary source indicates a lowest observed effect dose in the dose range for classification and labelling as harmful. The original report (Kodak 1971) was not available for review. The hazard category is consistent with that of the non-methylated analogue hydrquinone.
Secondary information indicates that the substance is less hazardous by the dermal route.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Information from RTECS database, limited information available (only species, exposure route and result), original study indicated to be reported in 1971.
- Principles of method if other than guideline:
- Rats were exposed to the test substance orally.
- GLP compliance:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Sex:
- not specified
- Dose descriptor:
- LDLo
- Effect level:
- 200 mg/kg bw
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The Material Safety Datasheet by Eastman on this substance (Revision Date: 04/17/2002, MSDSUSAIANSIIENI150000001305/Version 3.0) states that the LD50 in rats is "200 - 400 mg/kg". Since Eastman aquired Kodak, it is expected that this MSDS actually represents the original value of the Kodak study. For mice, the LD50 is indicated to be greater than 400 mg/kg bw.It is therefore considered, that for the purposes of classification and labelling, the LD50 is greater than 300 mg/kg bw.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
