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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study (GLP)
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006
Report date:
2006

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD 402, EC B.3, OPPTS 870.1200
Deviations:
no
Remarks:
24 hours exposure
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrakis(hydroxymethyl)phosphonium chloride, oligomeric reaction products with urea
EC Number:
500-057-6
EC Name:
Tetrakis(hydroxymethyl)phosphonium chloride, oligomeric reaction products with urea
Cas Number:
27104-30-9
Molecular formula:
C5H16ClN2O5P
IUPAC Name:
Phosphonium, tetrakis(hydroxymethyl)-, chloride (1:1), polymer with urea
Details on test material:
technical product

Test animals

Species:
rat
Strain:
Wistar

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
no
Amount / concentration applied:
2000 mg/kg bw
Duration of treatment / exposure:
24 hours
Observation period:
14 days
Number of animals:
5m, 5fm

Results and discussion

In vivo

Results
Irritation parameter:
other: scar formation
Basis:
animal #3
Time point:
other: day 9 post exposure
Score:
1
Max. score:
1
Reversibility:
not reversible
Remarks on result:
other: female rats

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
2000 mg/kg bw of Aflammit SAP is corrosive to skin after 24 hours exposure. Scar formation becomes visible at day 9 post application.