Registration Dossier
Registration Dossier
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EC number: 451-000-6 | CAS number: -
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Remarks:
- The type of method is based on a preliminary test, where the water solubility was determined to be >0.01g/l.
Test material
- Reference substance name:
- benzene, 1,4-bis[2-[3,5-dimethoxy-4-(1- methylpropoxy)phenyl]ethenyl]-
- Cas Number:
- 586410-55-1
- Molecular formula:
- C34 H42 O6
- IUPAC Name:
- benzene, 1,4-bis[2-[3,5-dimethoxy-4-(1- methylpropoxy)phenyl]ethenyl]-
- Details on test material:
- Read-across from CASRN586410-55-1 to the substance defined in section 1 allowed by belgian authority.
Standard solutions of test substance were prepared in acetonitrile. Standard solutions were sonicated for 5 minutes in order to dissolve the test substance.
On each day of analysis, calibration solutions in 50/50 (v/v) acetonitrile/double distilled water were made up from two standard solutions.
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- < 0.002 mg/L
- Temp.:
- 20 °C
- pH:
- 7.8
- Details on results:
- Due to the extremely low concentration of test substance found in all water solubility samples, and the accuracy of the method at these concentration levels (concentrations were at detection limit level), a large deviation between the high and low flow rate was observed. Therefore, it was decided to report the water solubility as <0.0016mg/l, i.e. the highest concentration of test substance measured (outliers excluded).
The study integrity was not adversely affected by the deviation (between both flow rates).
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
Due to thehigh log Pow (>4), the low water solubility (<1mg/l), the 48EC50 and 72LC50 which might both be >100mg/l and the non-readily biodegradability, the substance should be classified for 'chronic aquatic toxicity' (DSD: R53, CLP: cat.4).
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