EU-MEDICAL_DEVICES_REGULATION-ANX_I_SEC_10

Medical Devices Regulation - Hazardous Substances

EU. Hazardous Substances for Purposes of Medical Devices Regulation 2017/745/EU, 5 May 2017, as amended by Regulation 2020/561/EU, 24 April 2020

This list contains hazardous substances for purposes of the Medical Devices Regulation (MDR), based on the legislation's Annex I general safety and performance requirements, including for chemical, physical and biological properties. Specifically, the non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list).

Last updated 14 lipnja 2024. Database contains 4917 unique substances/entries.
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-
5787-96-2
Acute Tox. 3; STOT RE 2
Details
C.I. REACTIVE YELLOW 138:1
403-810-6
140876-13-7
Eye Dam. 1
Details
REAKTIVROT 2713
412-490-7
-
Skin Sens. 1
Details
C.I. REACTIVE RED 231
402-150-6
-
Eye Irrit. 2; Skin Sens. 1
Details
SUMIFIX BRILLIANTBLAU GL KONZENTRAT
414-100-0
154336-20-6
Eye Dam. 1
Details
425-830-4
-
Eye Dam. 1
Details
432-240-0
12056-51-8
Carc. 2
Details
ORANGE DER 8068
422-980-2
187026-95-5
Eye Dam. 1
Details
245-387-9
23031-36-9
Acute Tox. 3; Acute Tox. 4
Details
266-994-5
67747-09-5
Acute Tox. 4
Details
BROWN JR 547
419-260-5
-
Eye Dam. 1
Details
425-740-5
-
Eye Dam. 1
Details
255-255-2
41198-08-7
Acute Tox. 4
Details
247-656-6
26399-36-0
Eye Irrit. 2
Details
604-105-8
139001-49-3
Carc. 2; Repr. 2; Skin Sens. 1
Details
220-113-0
2631-37-0
Acute Tox. 3
Details
203-471-2
107-19-7
Flam. Liq. 3; Acute Tox. 3; Skin Corr. 1B
Details
217-638-2
1918-16-7
Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
Details
200-746-9
71-23-8
Flam. Liq. 2; Eye Dam. 1; STOT SE 3
Details
200-661-7
67-63-0
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
Details
204-623-0
123-38-6
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
Details
200-827-9
74-98-6
Flam. Gas 1; Press. Gas
Details
211-914-6
709-98-8
Acute Tox. 4
Details
219-006-1
2312-35-8
Carc. 2; Acute Tox. 3; Skin Irrit. 2; Eye Dam. 1
Details
205-359-9
139-40-2
Carc. 2
Details
204-062-1
115-07-1
Flam. Gas 1; Press. Gas
Details
262-104-4
60207-90-1
Repr. 1B; Acute Tox. 4; Skin Sens. 1
Details
620-365-5
9016-72-2
Acute Tox. 4; STOT RE 2; Skin Sens. 1
Details
201-176-3
79-09-4
Skin Corr. 1B
Details
204-638-2
123-62-6
Skin Corr. 1B
Details
201-170-0
79-03-8
Flam. Liq. 2; Skin Corr. 1B
Details
204-043-8
114-26-1
Acute Tox. 3
Details
204-498-2
121-79-9
Acute Tox. 4; Skin Sens. 1
Details
203-686-1
109-60-4
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
Details
203-687-7
109-61-5
Flam. Liq. 2; Acute Tox. 3; Skin Corr. 1B
Details
203-798-0
110-74-7
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
Details
203-389-7
106-36-5
Flam. Liq. 3; Acute Tox. 4
Details
203-132-9
103-65-1
Flam. Liq. 3; Asp. Tox. 1; STOT SE 3
Details
203-572-1
108-32-7
Eye Irrit. 2
Details
200-879-2
75-56-9
Flam. Liq. 1; Carc. 1B; Muta. 1B; Acute Tox. 3; Acute Tox. 4; Eye Irrit. 2; STOT SE 3
C Carcinogenic (article 57a)
M Mutagen (article 57b)
Details
201-155-9
78-90-0
Flam. Liq. 3; Acute Tox. 4; Skin Corr. 1A
Details
620-432-9
2122-19-2
Repr. 2; Acute Tox. 4
Details
245-951-4
23950-58-5
Carc. 2
Details
606-168-7
189278-12-4
Carc. 2
Details
PROSULFOCARB
401-730-6
52888-80-9
Acute Tox. 4; Skin Sens. 1
Details
619-000-2
94125-34-5
Acute Tox. 4
Details
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Proteinase, Mucor aspartic EC / List no: 232-975-5 | CAS no: 9073-79-4
Proteinase, pancreatic EC / List no: 232-626-7 | CAS no: 9001-72-3
Proteinase, aspartic EC / List no: 278-856-1 | CAS no: 78169-47-8
Proteinase, Aspergillus alkaline EC / List no: 232-977-6 | CAS no: 9074-07-1
Proteinase, Bacillus subtilis metallo- EC / List no: 232-991-2 | CAS no: 9080-56-2
Proteinase, oryzin EC / List no: 232-992-8 | CAS no: 9081-30-5
Proteinase, Streptomyces griseus EC / List no: 232-909-5 | CAS no: 9036-06-0
Proteinase, Aspergillus acid EC / List no: 232-796-2 | CAS no: 9025-49-4
Proteinase, Tritirachium album serine EC / List no: 254-457-8 | CAS no: 39450-01-6
Proteinase, Bothrops atrox serine EC / List no: 232-918-4 | CAS no: 9039-61-6
Bacteria, complex with amylase and proteinase EC / List no: - | CAS no: 68920-42-3
Proteinase, Myxobacter AL-1, II EC / List no: 276-716-4 | CAS no: 72561-05-8
Proteinase, submandibular gland serine, A EC / List no: 279-893-6 | CAS no: 82047-85-6
Proteinase, Bacillus subtilis serine EC / List no: 266-557-9 | CAS no: 67051-83-6
Proteinase, Serratia extracellular EC / List no: 253-457-5 | CAS no: 37312-62-2
Proteinase, Aspergillus oryzae neutral EC / List no: 232-990-7 | CAS no: 9080-55-1
Proteinase, Myxobacter α-lytic EC / List no: 253-448-6 | CAS no: 37288-76-9
Proteinase, microbial alkaline EC / List no: 256-863-0 | CAS no: 50936-53-3
Proteinase, Aspergillus parasiticus neutral EC / List no: 254-418-5 | CAS no: 39335-09-6
Proteinase, bacterial E 30 serine EC / List no: - | CAS no: 39369-34-1
Proteinase, rhizopus acid EC / List no: 812-486-9 | CAS no: 9074-09-3
Proteinase, Bacillus polymyxa neutral EC / List no: 255-914-4 | CAS no: 42613-33-2
Proteinase, Agkistrodon serine EC / List no: 232-933-6 | CAS no: 9046-56-4
Proteinase, serine EC / List no: 253-431-3 | CAS no: 37259-58-8
Myxobacteralphalyticproteinase EC / List no: - | CAS no: 12585-31-8
Aspergillin M EC / List no: - | CAS no: 42615-60-1
Proteinase, Bacillus neutral EC / List no: 278-547-1 | CAS no: 76774-43-1
Proteinase, Bacillus alkaline EC / List no: 232-972-9 | CAS no: 9073-77-2
Amylase, mixture with proteinase EC / List no: 685-079-5 | CAS no: 9001-11-0
Proteinase, microbial neutral EC / List no: 232-966-6 | CAS no: 9068-59-1
Proteinase, Bacillus alcalophilus serine EC / List no: 306-090-0 | CAS no: 95979-76-3
Bacillus megaterium protease fermentation product EC / List no: - | CAS no: 68909-17-1
Proteinase, Aspergillus niger neutral EC / List no: 254-422-7 | CAS no: 39346-39-9
Amylase, mixed with proteinase, Bacillus cereus-fermented EC / List no: - | CAS no: 68909-35-3
Proteinase, Aspergillus melleus, semialkaline EC / List no: - | CAS no: 76106-83-7
Proteinase, Endothia aspartic EC / List no: 253-395-9 | CAS no: 37205-60-0
Proteinase, Staphylococcus aureus serine EC / List no: 259-611-8 | CAS no: 55354-32-0
Proteinase, Aspergillus neutral EC / List no: 278-588-5 | CAS no: 77000-13-6
Proteinase, Bacillus subtilis EC / List no: 257-520-8 | CAS no: 51931-23-8
Proteinase, serine (Tritirachium album) EC / List no: 686-165-5 | CAS no: 102925-54-2
Thrombin EC / List no: 232-648-7 | CAS no: 9002-04-4
Proteinase, Bacillus licheniformis serine EC / List no: 279-361-3 | CAS no: 79986-26-8
Proteinase, microbial acid EC / List no: 256-862-5 | CAS no: 50936-52-2
Proteinase, Bacillus subtilis, sutilain EC / List no: 235-390-3 | CAS no: 12211-28-8
934-013-6
39450-01-6
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1
Details
232-966-6
9068-59-1
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1
Details
218-893-2
2275-18-5
Acute Tox. 1; Acute Tox. 2
Details
205-443-5
140-93-2
Acute Tox. 4; Skin Irrit. 2
Details
602-927-1
123312-89-0
Carc. 2; Repr. 2
Details
605-747-1
175013-18-0
Acute Tox. 3; Skin Irrit. 2
Details
429-520-1
4023-02-3
Acute Tox. 4; STOT RE 2; Eye Dam. 1; Skin Sens. 1
Details
236-656-1
13457-18-6
Acute Tox. 4
Details
-
108-34-9
Acute Tox. 2; Acute Tox. 1
Details
204-927-3
129-00-0
PBT Persistent, Bioaccumulative and Toxic (article 57d)
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
-
-
Acute Tox. 4
Details
PYRIDABEN
405-700-3
96489-71-3
Acute Tox. 3
Details
605-845-4
179101-81-6
Skin Sens. 1
Details
259-686-7
55512-33-9
Acute Tox. 4; Skin Irrit. 2; Skin Sens. 1
Details
203-809-9
110-86-1
Flam. Liq. 2; Acute Tox. 4
Details
The complex combination of polyalkylated pyridines derived from coal tar distillation or as high-boiling distillates approximately above 150°C (302°F) from the reaction of ammonia with acetaldehyde, formaldehyde or paraformaldehyde.
269-929-9
68391-11-7
Carc. 1B; Muta. 1B
Details
223-296-5
3811-73-2
Acute Tox. 3; Acute Tox. 4; STOT RE 1; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1
Details
240-062-8
15922-78-8
Acute Tox. 3; Acute Tox. 4; STOT RE 1; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1
Details
236-671-3
13463-41-7
Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1; Eye Dam. 1
Details
This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77588.
232-382-1
8012-00-8
R Toxic for reproduction (article 57c)
Details
201-762-9
87-66-1
Muta. 2; Acute Tox. 4
Details
611-516-6
57369-32-1
Acute Tox. 4
Details
610-007-6
422556-08-9
Skin Sens. 1
Details
264-151-6
63449-41-2
Acute Tox. 4; Skin Corr. 1B
Details
237-031-6
13593-03-8
Acute Tox. 3; Acute Tox. 4
Details
BAS 514 H
402-780-1
84087-01-4
Skin Sens. 1
Details
220-529-2
2797-51-5
Carc. 2; Repr. 2; Acute Tox. 4; STOT RE 2; Eye Irrit. 2; Skin Sens. 1A
Details
205-711-1
148-24-3
Repr. 1B; Acute Tox. 3; Eye Dam. 1; Skin Sens. 1
Details
202-051-6
91-22-5
Carc. 1B; Muta. 2; Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2
Details
219-455-3
2439-01-2
Repr. 2; Acute Tox. 4; STOT RE 2; Eye Irrit. 2; Skin Sens. 1
Details
602-997-3
124495-18-7
Skin Sens. 1
Details
201-435-0
82-68-8
Skin Sens. 1
Details
PANTERA; QUIZALOFOP-P-TEFURYL
414-200-4
119738-06-6
Carc. 2; Repr. 2; Acute Tox. 4; STOT RE 2
Details
SCH.19927 DIBENZOYLTARTRATE
404-390-7
88976-55-0
Flam. Sol. 1; Skin Sens. 1
Details
(R)-EPICHLOROHYDRIN
424-280-2
51594-55-9
Flam. Liq. 3; Carc. 1B; Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1
Details
A complex combination of hydrocarbons obtained as the raffinate from the UDEX extraction process on the catalytic reformer stream. It consists of saturated hydrocarbons having carbon numbers predominantly in the range of C6 through C9.
270-088-5
68410-71-9
Carc. 1B; Muta. 1B; Asp. Tox. 1
Details
The complex combination of hydrocarbons obtained as a raffinate from a Lurgi separation unit. It consists predominantly of non-aromatic hydrocarbons with various small amounts of aromatic hydrocarbons having carbon numbers predominantly in the range of C6 through C8.
270-349-3
68425-35-4
Carc. 1B; Muta. 1B; Asp. Tox. 1
Details
307-769-4
97722-19-5
Press. Gas; Flam. Gas 1; Carc. 1A; Muta. 1B
Details
SCARLET DER 8107
429-070-4
214362-06-8
Eye Dam. 1
Details
LATEMUL S-180 A
410-540-2
116726-92-2
Skin Irrit. 2; Skin Sens. 1
Details
604-398-2
144171-61-9
Acute Tox. 3; Acute Tox. 4; STOT RE 1; Skin Sens. 1B
Details
DESBIMID
401-970-1
-
Skin Sens. 1
Details
-
-
Muta. 2; Repr. 1B
Details
447-920-2
897393-42-9
Repr. 2; Acute Tox. 4; Skin Corr. 1B; Eye Dam. 1
Details
473-390-7
-
VPVB very Persistent and very Bioaccumulative (article 57e)
Details
C.I. DIRECT YELLOW 166; DIRECT YELLOW 166; GIALLO DIRETTO 166; JAUNE DIRECT 166; MONOAZO YELLOW MA 2822
403-410-1
114565-65-0
Skin Sens. 1
Details
KAYARAD R-825
405-360-6
-
Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
Details
ADINE CP 31
401-740-0
-
Acute Tox. 4
Details
915-270-3
-
R Toxic for reproduction (article 57c)
Details
632-619-2
881685-58-1
Carc. 2; Repr. 1B; Skin Sens. 1B
Details
-
-
Repr. 1B
Details
-
-
Repr. 1B
Details
PK 323
401-940-8
-
Acute Tox. 4; Eye Irrit. 2
Details
CARTASOL RED K-2BN; RED 10 25 501
408-000-6
118658-98-3
STOT RE 2; Skin Sens. 1
Details
X 3761
400-930-0
-
Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
Details
PROJET 780 NP; SUBSTANCE SC101756
407-700-9
101408-30-4
Skin Sens. 1
Details
HOSTAVIN N 24; SANDUVOR 3050; VP SANDUVOR 3050
400-580-9
85099-50-9
Skin Irrit. 2
Details
PS-6 SENSITIZER
413-840-1
121870-66-4
Self-react. C
Details
1-DODECENE DIMER, HYDROGENATED; ALKANE 2
417-060-2
151006-61-0
Acute Tox. 4
Details
MARLOTHERM L
405-470-4
73807-39-3
Skin Irrit. 2
Details
MCP 968
410-190-0
132983-41-6
Eye Irrit. 2
Details
SUBSTANCE S166075
424-270-8
-
Eye Dam. 1
Details
UNISOL S
405-760-0
-
Eye Dam. 1; Skin Sens. 1
Details
EMULGATOR SWA; EMULVIN SWA
406-325-8
-
Acute Tox. 4
Details
430-200-7
-
Eye Dam. 1
Details
ETHOXYLATED POLYESTER RESIN
405-960-8
-
Skin Sens. 1
Details
ROBAC AS/100
403-030-6
137398-54-0
Acute Tox. 4; Skin Sens. 1
Details
MPA
402-090-0
87025-52-3
Skin Corr. 1B
Details
SPIRAMBRENE
416-930-9
121251-67-0
Skin Irrit. 2
Details
429-860-9
86803-90-9
Skin Sens. 1
Details
434-290-9
249630-78-2
Acute Tox. 4
Details
425-530-3
98769-75-6
Acute Tox. 4; Eye Dam. 1
Details
LOVASTATIN FREE ACID
415-840-7
-
Skin Sens. 1
Details
442-480-8
-
Org. Perox. C; Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1
Details
433-640-8
-
Pyr. Sol. 1
Details
427-040-5
-
Skin Corr. 1B
Details
426-530-6
-
Skin Irrit. 2
Details
430-690-2
52783-21-8
Skin Irrit. 2
Details
GA1270; HOE S 4096
407-290-1
-
Eye Dam. 1
Details
PEROXIMON S 168 TECHNICALLY PURE
410-840-3
71566-50-2
Org. Perox. C
Details
KEROFLUX ES 3241
406-640-0
136920-07-5
Skin Sens. 1
Details
434-330-5
-
Carc. 2; Skin Sens. 1
Details
Z-19
414-520-4
-
Skin Irrit. 2; Eye Dam. 1
Details
419-610-7
171866-24-3
STOT RE 2
Details
PEROXIMON 180
412-140-3
32144-25-5
Org. Perox. D
Details
CYASORB UV-3853 LIGHT STABILIZER; DASTIB 845; SANDUVOR 845
415-430-8
86403-32-9
Eye Dam. 1; Skin Sens. 1
Details
HIGHLINK DM
421-890-0
51673-84-8
Skin Sens. 1
Details
429-710-2
-
Self-react. D; Acute Tox. 4
Details
EXPERIMENTAL CROSSLINKER S17762-80(S); MELAMINE BASED CROSSLINKER (MBC); TACT
420-390-1
187547-46-2
Skin Sens. 1
Details
442-300-8
-
Skin Sens. 1
Details
429-590-1
-
Skin Sens. 1
Details
F1 MINERAL FLOTATION COLLECTOR (40% HTEA.HCL)
405-720-2
-
Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
Details
RED E190
411-560-4
-
STOT RE 1; Skin Sens. 1
Details
AF-376
407-740-7
138427-56-2
Skin Irrit. 2; Skin Sens. 1
Details
428-050-2
-
Skin Sens. 1
Details
VIKOFLEX 9080
414-890-7
71302-79-9
Skin Sens. 1
Details
SPE 93279
414-420-0
-
Eye Dam. 1
Details
419-000-0
-
Skin Sens. 1
Details
EUGEWHITE
412-020-0
-
Skin Sens. 1
Details
FLORASANTOL
415-990-3
67739-11-1
Eye Irrit. 2
Details
MMA-10R
423-670-1
-
Eye Dam. 1; Skin Sens. 1
Details
UVA RAR 1018
423-520-3
156137-33-6
Skin Sens. 1
Details
442-800-6
-
Skin Irrit. 2
Details
432-190-1
182176-52-9
Acute Tox. 4; STOT RE 2; Eye Dam. 1
Details
425-910-9
32480-08-3
Skin Irrit. 2
Details
ROT Y; RUBINOT Y; RUBINROT Y
408-240-1
-
Acute Tox. 4
Details
440-510-4
-
Eye Dam. 1; Skin Sens. 1
Details
442-290-5
457624-86-1
Eye Dam. 1
Details
435-440-6
-
Eye Dam. 1
Details
431-440-5
-
Eye Dam. 1
Details
FORMYLTRICYCLODECEN, EXO
410-480-7
-
Skin Sens. 1
Details
NEOCASPIRENE
412-460-3
89079-92-5
Skin Irrit. 2
Details
-
8069-76-9
Acute Tox. 4
Details
427-050-1
170016-25-8
Repr. 2; Skin Irrit. 2; Skin Sens. 1
Details
T-69
414-770-4
140698-96-0
Self-react. C; Carc. 2
Details
423-750-4
-
Eye Irrit. 2
Details
R 7623 TECHNICAL
403-250-2
-
Carc. 2; Repr. 1B; Acute Tox. 4
Details
451-440-9
586372-44-3
Eye Dam. 1
Details
427-730-6
202420-04-0
Skin Corr. 1B
Details
T-4240 FLUOROCHEMICAL URETHANE DERIVATIVE
413-640-4
-
STOT RE 2
Details
BONJET BLACK 817
418-230-9
163879-69-4
Expl. 1.3; Repr. 2; STOT RE 2; Skin Sens. 1
Details
611-341-5
55965-84-9
Acute Tox. 2; Acute Tox. 3; Skin Corr. 1C; Eye Dam. 1; Skin Sens. 1A
Details
MONO 442
412-260-6
52658-19-2
Eye Irrit. 2; Skin Sens. 1
Details
INTERMEDIAIRE AR HT 3728
410-065-0
-
Skin Sens. 1
Details
DP 15
410-640-6
-
Skin Irrit. 2; Eye Dam. 1
Details
AMMONIUM DIAS
407-320-3
-
Skin Irrit. 2; Eye Dam. 1
Details
A-88820.605
414-810-0
-
STOT RE 2; Eye Dam. 1
Details
MCP 455
406-240-6
-
Flam. Liq. 3; Skin Corr. 1B
Details
MDI
406-550-1
-
Skin Sens. 1
Details
422-920-5
-
STOT RE 2
Details
417-050-8
151006-58-5
Acute Tox. 4
Details
DOW CORNING (R) 4-2920 INTERMEDIATE
406-930-7
96-29-7
STOT RE 1; Skin Sens. 1
Details
SP 7053
415-930-6
-
Repr. 2; Skin Sens. 1
Details
429-990-6
-
Eye Dam. 1; Skin Sens. 1
Details
VESTAGON EP S 270
411-830-1
114765-88-7
Eye Dam. 1; Skin Sens. 1
Details
CAMONAL
426-130-1
166301-21-9
Skin Irrit. 2
Details
422-260-8
20701-68-2
Eye Dam. 1
Details
NEWLON AM-92I
407-490-9
-
Acute Tox. 4; Skin Corr. 1B
Details
MUGETANOL
407-640-3
63767-86-2
Eye Irrit. 2; Skin Irrit. 2
Details
427-140-9
-
Carc. 2
Details
435-960-3
-
Carc. 1B; Muta. 1B; Skin Sens. 1
Details
DYE K
402-660-9
-
Repr. 1B
Details
426-840-1
-
Eye Dam. 1
Details
DOWFAX (R) DRY HYDROTROPE POWDER
429-650-7
147732-60-3
Eye Irrit. 2
Details
PRIAZUL LAUROYL LACTYLATE; PRICARE LAURYL LACTYLATE (1:1.5)
412-590-0
58856-63-6
Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
Details
PRICARE
411-860-5
-
Skin Sens. 1
Details
VP SANDUVOR 3052 LIQUIDE
405-670-1
119530-69-7
Acute Tox. 4; STOT RE 2; Skin Corr. 1B
Details
434-420-4
-
Skin Irrit. 2; Eye Dam. 1
Details
427-090-8
116044-44-1
Skin Sens. 1
Details
FRUITATE
407-520-0
80657-64-3
Skin Irrit. 2
Details
CYANEX (R) EXTRACTANT; CYANEX 923 EXTRACTANT
403-470-9
-
Skin Corr. 1B
Details
BONTRON E-88
406-890-0
130296-87-6
Acute Tox. 4
Details
MCP 938
410-720-0
141847-13-4
Eye Dam. 1
Details
435-450-0
5460-63-9
Skin Sens. 1
Details

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