Registration Dossier
Registration Dossier
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EC number: 209-283-7 | CAS number: 565-62-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Read across to CAS # 141-79-7, EC # 205-502-5, 4-Methylpent-3-en-2-one, Mesityl Oxide, key experimental study conducted according to OECD Guideline 404 (Acute Dermal Irritation / Corrosion) in 2010. These results indicate that the test item, Mesityl oxide, has an irritant effect on the skin of the rabbit following a 4 hour dermal exposure period, even though with a high individual variability. Reaction was moderately stronger in one animal and recovery was not completed in two animals at the end of the 14-day observation period.
Justification for selection of eye irritation endpoint:
1) Read across to CAS # 141-79-7, EC # 205-502-5, 4-Methylpent-3-en-2-one, Mesityl Oxide, key experimental study conducted according to OECD 437 "Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants (adopted 7 September 2009) in 2010. The treatment with the test item induced a slight effect on corneal opacity and a strong effect on corneal permeability. According to the criteria stated in the OECD guideline for this test, the test item is not defined as corrosive or severely irritant to the eye. However, since the calculated IVIS value is near to the threshold of severe irritancy/corrosion, the test item might have an irritating potential in vivo.
2) Read across to CAS # 141-79-7, EC # 205-502-5, 4-Methylpent-3-en-2-one, Mesityl Oxide, experimental results cccording to Carpenter and Smyth, Am. J. Ophth. 29: 1363, 1946. Mesityl oxide scored an injury grade of 5 (i.e., 0.02 mL undiluted test compound gives a score of over 5.0 points and 0.005 mL not over 5.0 points - out of a maximum of 20) on a scale of 1 to 10, 18 to 24 hours after instillation into the eyes of rabbits. Based on the results of the study, the test substance has to be regarded as a potential eye irritant.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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