3-methylpent-3-en-2-one

Endpoint summary

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Justification for selection of acute toxicity – oral endpoint
Read across to CAS # 141-79-7, EC # 205-502-5, Mesityl Oxide, key experimental study using the acute toxic class method according to OECD Guideline 423 (Acute Oral toxicity) was conducted in 2010. These results indicate that the test item, Mesityl oxide, has severe toxic effects at 2000 mg/kg while some toxic effect, shortly reversible, were observed following oral administration of a single dose at a level of 300 mg/kg.
The mortality pattern demonstrates the LD50 to be greater than 300 but less than 2000 mg/kg body weight.

Justification for selection of acute toxicity – inhalation endpoint
Read across to CAS # 141-79-7, EC # 205-502-5, Mesityl Oxide:
1) Hine et al. (1960) determined the 4-hr LC50 in rats to be 1130 ppm.
2) Carpenter et al. (1949) subjected groups of six male or female Sherman rats to increasing concentrations of mesityl oxide over a 4-hour period until two of the four animals died within the 14-day observation period. They found that a concentration of 1000 ppm was necessary to produce this mortality.
3) Experimental result fromstandard acute method, 1939. Rabbits were exposed to atmospheres containing 0.6% to 2.4% mesityl oxide. Rabbits showed ocular and upper respiratory tract irritation when they inhaled 1.3% mesityl oxide for 30 or 90 minutes.
4) Experimental result from standard acute method, 1939. Mice were exposed to atmospheres containing 0.6% to 2.4% mesityl oxide. Mice died after 23 minutes of exposure at 2.4% mesityl oxide and experienced dyspnea, convulsions, narcosis, vasodilatation, and cyanosis just prior to death. Mice also died at 84 minutes after exposure at 1.3% mesityl oxide in air or at 135 minutes after exposure at 0.6%.
5) Hine et al. (1960) determined the 4-hr LC50 in mice to be between 2000 and 4000 ppm.
6) Experimental result from standard acute method reported, 1942. Smyth et al. exposed male rats (n=10) to high concentrations for short periods. Exposure to 13,000 ppm (53,170 mg/m3) caused mortality in 0, 16, 20, and 100% of the animals at 10, 15, 30, and 60 minutes, respectively. When exposed to 500, 1000, or 2500 ppm (2045, 4090, and 10,225 mg/m3), 30, 68, and 100% of the animals died after 8 hours. Results from post-mortem examination indicated narcotic death with some lung irritation
7) Experimental result from using the standard acute method reported in 1942. Smyth et al. exposed male rats (n=10) to high concentrations for short periods. Exposure to 13,000 ppm (53,170 mg/m3) caused mortality in 0, 16, 20, and 100% of the animals at 10, 15, 30, and 60 minutes, respectively.

Justification for selection of acute toxicity – dermal endpoint
Read across to CAS # 141-79-7, EC # 205-502-5, Mesityl Oxide, key experimental result using the acute toxic class method equivalent or similar to to OECD Guideline 402 ((Acute Dermal Toxicity) was conducted in 1980. The acute dermal LD50 was reported to be 5150 mg/kg for the rabbit.