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Diss Factsheets
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EC number: 211-706-5 | CAS number: 688-74-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Tributyl borate is rapidly hydrolyzed to Boric acid and n-Butanol in the presence of water or moisture in the air (18.3 sec at 21°C). Reliable endpoint data of the hydrolysis products n-Butanol and Boric acid are used, which is entirely appropriate to draw conclusions on the acute toxicity of Tributyl borate by the oral route:
1) Hydrolysis product n-Butanol
LD50 in female rats: 2290 mg/kg bw.
2) Hydrolysis product Boric acid
- LD50 in male rats: 3450 mg/kg bw (2950 - 4040 mg/kg bw);
- LD50 in female rats 4080 mg/kg bw (3640 - 4560 mg/kg bw).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: experimental study on hydrolysis product Boric acid
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions.
- Qualifier:
- according to guideline
- Guideline:
- other: No data
- Deviations:
- not specified
- Principles of method if other than guideline:
- Boric acid was administered orally by gavage to six groups of five male and five female albino Sprague-Dawley rats. The test material was administered as a 50 % w/v suspension in 0.5 % aqueous methyl cellulose at dosage levels of 2.0; 2.5; 3.16; 3.98; 5.01 and 6.31 g/kg bw. Rats were fasted for a period of 3 to 4 h prior to dosage. Animals were observed for mortality and toxic effects at 1, 2, 4, and 24 h and once daily after for a total of 14 days. At the end of the observation period the surviving animals were weighed sacrificed and autopsies were performed.
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: Males: 267 - 302 g; Females: 214 - 248 g - Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5 % aqueous methyl cellulose
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50 % w/v
MAXIMUM DOSE VOLUME APPLIED: 3450 - 4080 mg/kg bw - Doses:
- 2.0; 2.5; 3.16; 3.98; 5.01 and 6.31 g/kg bw.
- No. of animals per sex per dose:
- Five animals/group; no further data
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs - Statistics:
- Litchfield and Wilcoxon
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 450 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 950 - 4 040
- Remarks on result:
- other: mg boric acid/kg
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 080 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 640 - 4 560
- Remarks on result:
- other: mg boric acid/kg bw
- Mortality:
- No data
- Clinical signs:
- Symptoms include sings of CNS depression, ataxia, convulsions, laboured breathing or rapid respiration; blood crust around nose, marked diarrhoea and ptosis.
- Body weight:
- No data
- Gross pathology:
- Autopsies indicated congestion of lungs, kidneys and adrenals; inflammation of the pyloric portion of stomach and small intestine.
- Other findings:
- No data
- Interpretation of results:
- other: EU-GHS criteria not met
- Conclusions:
- The acute oral LD50 of boric acid for male albino rats was 3450 (2950 - 4040) mg boric acid/kg, equivalent to 604 mg B/kg bw. In female albino rats the acute oral LD50 of boric acid was 4080 (3640 - 4560) mg boric acid/kg, equivalent to 714 mg B/kg bw.
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: experimental study on hydrolysis product n-Butanol
- Adequacy of study:
- key study
- Study period:
- 1967
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Test material was administered by oral gavage to rats at various dose levels. Survivors were observed for 14 days after dosing.
- GLP compliance:
- no
- Remarks:
- performed prior to GLP
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: Harlan Wistar
- Sex:
- female
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Dosage levels differ by a factor of 2 in a geometric series.
- No. of animals per sex per dose:
- Number of female rats used not stated in report but typically 6 rats are used/dose level.
- Control animals:
- no
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2.83 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 292 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: converted value (calculated with a density 0.81 g/mL)
- Interpretation of results:
- other: EU-GHS criteria not met
- Conclusions:
- LD50 in female rats: 2.83 ml/kg, corresponding to 2290 mg/kg bw
- Executive summary:
The acute oral toxicity of n-butanol was determined in a study comparable to OECD TG 401.
60-day-old female Harlan Wistar rats were dosed with the test material at various dose levels per gavage. The acute LD50 value was 2.83 mL/kg bw in female rats, corresponding to 2290 mg/kg bw (calculated with a density of 0.81 g/mL). No further data were available.
Referenceopen allclose all
No additional information available.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
The hydrolysis product boric acid does not require classification for lethal effects following single oral exposure according to Regulation 1272/2008/EC.
The hydrolysis product n-Butanol is listed in Annex VI to Regulation (EC) No 1272/2008 and classified with Cat. 4 oral (H302:" Harmful if swallowed"). As the classification in the Annex shall be considered as a minimum classification, the target substance Tributyl borate is classified in this hazard class as well.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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