Dihydrogen [[N,N'-ethylenebis[N-(carboxymethyl)glycinato]](4-)-N,N',O,O',ON,ON']nickelate(2-)

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Remarks:

Experimental data of read across substances

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data for the target chemical is summarized based on the read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

no guideline available

Principles of method if other than guideline:

WoE report is based on two short term toxicity to fish studies as-
WoE 2, WoE 3, WoE 4.

GLP compliance:

not specified

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: WoE 2: Lepomis macrochirus, WoE 3: Poecilia reticulata, WoE 4: Pimephales promelas

Details on test organisms:

Common Name: WoE 3: Bluegill
WoE 4 : Rainbow fish
WoE 5 : Fathead minnow

Test type:

static

Water media type:

freshwater

Total exposure duration:

96 h

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 159 - < 320 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: Test chemical was found to be non toxic.

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, on the basis of mortality effect of test chemical on fishes the 96 hr LC50 value was determined to be > 159 to < 320 mg/l

Executive summary:

Data available of the structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on fishes. The studies are as mentioned below:

The first includes study of short-term toxicity to fishes was carried out. The duration of study was 96 hr. Bluegill (Lepomis macrochirus) was taken as test organism. On the basis of mortality effect of test chemical on bluegill (Lepomis macrochirus) the 96 hr NOEC and LC50 value was determined to be 100 mg/l and 159 mg/l respectively. As per the value of LC50 the test chemical was considered as not classified as per CLP criteria. 

The second study was of short-term toxicity to fishes was carried out. The duration of study was 96 hr. Rainbowfish (Poecilia reticulata) was taken as test organism. On the basis of mortality effect of test chemical on rainbowfish (Poecilia reticulata) the 96 hr LC50 value was determined to be 320 mg/l. As per the value of LC50 the test chemical was considered as not classified as per CLP criteria. 

The third study includes short-term toxicity to fish. The duration of study was 96 hr. Fathead minnow (Pimephales promelas) was taken as test organism. On the basis of mortality effect of test chemical on fathead minnow (Pimephales promelas) the 96 hr LC50 value was determined to be 190 mg/l. As per the value of LC50 the test chemical was considered as not classified as per CLP criteria. 

On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, on the basis of mortality effect of test chemical on fishes the 96 hr LC50 value was determined to be > 159 to < 320 mg/l

Description of key information

On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, on the basis of mortality effect of test chemical on fishes the 96 hr LC50 value was determined to be > 159 to < 320 mg/l

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Dose descriptor:

LC50

Effect concentration:

> 159 - < 320 mg/L

Additional information

Data available of the structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on fishes. The studies are as mentioned below:

The first includes study of short-term toxicity to fishes was carried out. The duration of study was 96 hr. Bluegill (Lepomis macrochirus) was taken as test organism. On the basis of mortality effect of test chemical on bluegill (Lepomis macrochirus) the 96 hr NOEC and LC50 value was determined to be 100 mg/l and 159 mg/l respectively. As per the value of LC50 the test chemical was considered as not classified as per CLP criteria. 

The second study was of short-term toxicity to fishes was carried out. The duration of study was 96 hr. Rainbowfish (Poecilia reticulata) was taken as test organism. On the basis of mortality effect of test chemical on rainbowfish (Poecilia reticulata) the 96 hr LC50 value was determined to be 320 mg/l. As per the value of LC50 the test chemical was considered as not classified as per CLP criteria. 

The third study includes short-term toxicity to fish. The duration of study was 96 hr. Fathead minnow (Pimephales promelas) was taken as test organism. On the basis of mortality effect of test chemical on fathead minnow (Pimephales promelas) the 96 hr LC50 value was determined to be 190 mg/l. As per the value of LC50 the test chemical was considered as not classified as per CLP criteria. 

On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, on the basis of mortality effect of test chemical on fishes the 96 hr LC50 value was determined to be > 159 to < 320 mg/l

As per the above information the test chemical was considered as not classified as per CLP criteria.