Registration Dossier
Registration Dossier
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EC number: 247-019-2 | CAS number: 25481-21-4
Endpoint summary
Administrative data
Description of key information
Hydrolysis: Hydrolysis: Test chemical is not expected to undergo hydrolysis in the environment due to lack of functional groups that hydrolyze under environmental conditions.
Biodegradation in water: screening test: The biodegradability of the substance was calculated using seven different Biowin 1-7 models of the BIOWIN v4.10 software. The results indicate that the test chemical is expected to be 50 % biodegradable in 3.5395 weeks hence consider as not readily biodegradable.
Biodegradation in water: simulation tests: Estimated half life of test chemical in water was 37.5 days, 900 hr.
Biodegradation in sediment: simulation tests: Estimated half life of test chemical in sediment estimated to be 337.5 days, 8100 hr.
Biodegradation in soil : The biodegradation half-life of test substance in soil was estimated to be (75) days, 1800 hrs.
Adsorption: In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is scientifically not necessary and does not need to be conducted because the substance has low octanol water partition coefficient and adsorption potential of substance is related to this parameter.
Additional information
Hydrolysis: Hydrolysis: Test chemical is not expected to undergo hydrolysis in the environment due to lack of functional groups that hydrolyze under environmental conditions.
Biodegradation in water: screening test:
Predicted data of target chemical and supporting weight of evidence studies for it's structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on biodegradation. The studies are as mentioned below:
The first study includes Estimation Programs Interface Suite was run to predict the biodegradation potential of the test compound in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that the test chemical is expected to be 50 % biodegradable in 3.5395 weeks hence consider as not readily biodegradable.
The second study of biodegradation was also carried out. Duration of test was 28 days . Activated sludge was taken as inoculum. Concentration of sludge was taken as 30 mg/l. Concentration of test chemical was taken as 100 mg/l. Test chemical reached 0% degradation by O2 consumption parameter, in duration of 28 days. Thus test chemical was considered as not readily biodegradable in water.
On the basis of information mentioned above, the test chemical was considered as not readily biodegradable in water.
Biodegradation in water: simulation tests: Estimation Programs Interface prediction model was run to predict the half-life in water and sediment for the test compound. If released in to the environment, 50 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days ( 900 hrs). The half-life ( 37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low.
Biodegradation in sediment: simulation tests: Estimation Programs Interface prediction model was run to predict the half-life in sediment for the test compound. The half-life period of test chemical in sediment is estimated to be 337.5 days ( 8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0835 %), indicates that test chemical is not persistent in sediment.
Biodegradation in soil : The half-life period of test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 50 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Adsorption: In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is scientifically not necessary and does not need to be conducted because the substance has low octanol water partition coefficient and adsorption potential of substance is related to this parameter.
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