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EC number: 249-828-6 | CAS number: 29761-21-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
Description of key information
Delayed Neurotoxicity of Organophosphorus Substances Following Acute Exposure; Limit test (similar to OECD 418): NOAEL (neurotoxicity): ≤ 120000 mg/kg bw (total dose): no neurotoxic potential.
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 20 000 mg/kg bw/day
Effect on neurotoxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on neurotoxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the key acute delayed neurotoxicity study IDDPP was administered via gavage to each test animal (10 mature chickens) at a rate of 10000 mg/kg bw, twice daily for 3 consecutive days. The procedure was repeated following a 21-day observation period. The total dosage of IDDPP administered to each chicken was 120000 mg/kg. Positive control birds received a single oral dose of 0.5 g/kg tri-ortho cresyl phosphate (TOCP). Test and control-birds appeared normal throughout the 42-day test period. No signs of neurotoxicity (extreme weakness of legs and wings) were noted. Gross pathological examination of all animals revealed no abnormal tissue-alterations. Histopathologic examination of sections of brain, spinal cord and sciatic nerve revealed no lesions related to treatment with IDDPP. Based on these results, it is therefore concluded that IDDPP did not induce the neuropathologic alterations characteristic of delayed neurotoxicity in the hen, and the NOAEL for neurotoxicityogy was 20000 mg/kg bw/d.
Two supporting studies were available for neurotoxicity. Both were acute, oral, limit tests. In one study 10 hens were dosed with 25000 mg/kg (5000 mg/kg per day for 5 consecutive days) of IDDPP. The hens were observed for 21 days post dose. A second dose was given (20000/kg (5000 mg/kg per day for 4 consecutive days) of IDDPP, and hens observed an additional 21 days. No clinical neurotoxic response was detected during the first and second test period. No mortality occurred. Results from the biochemical method supported the clinical findings: no inhibition of the neurotoxic esterase was detected at 40000 mg/kg. Based on these results, it is concluded that IDDPP did not induce the neuropathologic alterations characteristic of delayed neurotoxicity in the hen, and the NOAEL for neurotoxicity was 5000 mg/kg bw/day.
In the other supporting study, performed similar to OECD 418, 10 mature chickens received 2 doses of IDDPP per day for 3 consecutive days, 10000 mg/kg at each dose. This dose schedule was repeated on Day 21. Ten positive control birds received a single oral dose of 0.5 g/kg tri-ortho cresyl phosphate (TOCP). All, except one, test birds appeared normal throughout the 42-day test period, exhibiting no signs of neurotoxicity. Histological examination of brain, spinal cord and sciatic nerve revealed no evidence of demyelination in any bird treated with IDDPP. Based on these results, it is therefore concluded that IDDPP did not induce the neuropathologic alterations characteristic of delayed neurotoxicity in the hen and the NOAEL for neurotoxicity was 20000 mg/kg.
Justification for classification or non-classification
Based on the available data, there is no evidence of neurotoxic effects for IDDPP. Therefore, based on the EU criteria outlined in 67/548/EEC and 1272/2008/EC IDDPP does not have to be classified with regard to neurotoxicity.
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