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Diss Factsheets
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EC number: 249-828-6 | CAS number: 29761-21-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
- Molecular weight - 390 g/mol
- Water solubility - 0.011 mg/L
- Log Kow - 6.11
- Vapour pressure - 66.5 Pa
No toxicokinetic studies are available. The available toxicity studies provide no or little information. Therefore the assessment is primarily based on physicochemical properties, supported by some toxicological indications.
Physical/chemical parameters
The physical/chemical properties that are of importance to assess the toxicokinetics behaviour of IDDPP are:
Absorption
IDDPP is highly lipophilic (based on log Kow) and therefore oral/GI-absorption by passive diffusion is expected to be limited. If any absorption occurs, micellular solubilisation will be the major mechanism, also based on the low water solubility and moderate low molecular weight of 390 g/mol. In a 90-day repeated dose toxicity oral feeding study (Naylor, M.W., 1986), IDDPP was found to cause significant effects on several haematology parameters at the lowest dose level of 140 ppm. In the mid and high dose, effects were observed on liver-related clinical parameters, relative liver weight, and histopathology of the liver. This indicates that oral absorption has occurred. . Acute toxicity tests give no additional information.
The same absorption patterns are considered to be applicable for respiratory absorption, although exposure via this route is unlikely based on the low vapour pressure. However, information from toxicology studies via this route is available. In one respiratory exposure study (Younger Fred M., 1968) male rats died 3-4 days after an 6h exposure (nominal exposure 1.74 mg/L). This indicates that respiratory absorption has occurred, although it gives no indication of the amount of absorbed substance.
Because of its highly lipophilic character the dermal penetration of IDDPP into the stratum corneum will be high. However, because of its very low water solubility the rate of penetration from the stratum corneum into the epidermis is likely to be low and therefore dermal absorption is considered to be low.
Distribution, metabolism and excretion
There is no information about the distribution, metabolism, excretion, bioavailability and accumulation of IDDPP. Based on the physical chemical properties the substance is likely to be distributed into cells and to a lower extent into the extracellular spaces. Since its highly lipophilic character it is anticipated that it tends to be accumulated in adipose tissues and in lipophilic layers like the stratum corneum. In the 90-day repeated dose toxicity oral feeding study (Naylor, M.W., 1986), IDDPP was found to cause increased liver weights and hepatocellular hypertrophy/hyperplasia and hepatocellular brown pigment were seen this might indicate that IDDPP is metabolized in the liver.
Conclusion:
IDDPP can be absorbed after oral and respiratory exposure, but the amount of absorption cannot be predicted. Dermal absorption is considered to be very low, however, accumulation in the stratum corneum is possible. No information is available about the distribution, metabolism and excretion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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