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Diss Factsheets
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EC number: 265-162-9 | CAS number: 64742-59-2 A complex combination of hydrocarbons obtained by treating a petroleum fraction with hydrogen in the presence of a catalyst. It consists of hydrocarbons having carbon numbers predominantly in the range of C13 through C50 and boiling in the range of approximately 230°C to 600°C (446°F to 1112°F). This stream is likely to contain 5 wt. % or more of 4- to 6- membered condensed ring aromatic hydrocarbons.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No experimental data were located on the absorption, distribution, metabolism or elimination of Heavy Fuel Oil Components in vivo.
Physicochemical considerations suggest that uptake across skin is possible but will be relatively low since only around 2% of the hydrocarbon blocks present have a log Pow <5 (ECHA, 2008). This is supported by results from animal acute dermal toxicity testing.
Low water solubility of Heavy Fuel Oil Components combined with results from a rat acute inhalation toxicity study suggest that uptake across the lung following inhalation exposure is low.
Modelled information indicates that the majority of hydrocarbon substances present in Heavy Fuel Oil Components have a predicted log Pow of >5, making uptake by micellar solubilisation possible following oral exposure. However, while the extent of the uptake is uncharacterized, oral LD50 values in the range 4 g/kg bw/d to >25 g/kg bw/d suggest this is low, or that the absorbed components are of low intrinsic toxicity.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
No experimental data were located on the absorption, distribution, metabolism or elimination of Heavy Fuel Oil Components in vivo. This is not unexpected given the predictable technical difficulties associated with characterising the fate of complex UVCB petroleum substances in the body.
Physicochemical considerations suggest that uptake across skin is possible but will be relatively low since only around 2% of the hydrocarbon blocks present have a log Pow <5 (ECHA, 2008). This is supported by results from animal acute dermal toxicity testing, where no mortality and only limited (gross) systemic changes were recorded following 24 h occluded exposure to 2-5 g/Kg bw of test substance, indicating that uptake by undamaged skin was limited; or that the absorbed hydrocarbon components were of low inherent toxicity. No measured data are available on the distribution or metabolic fate of Heavy Fuel Oil Components.
Results from a rat acute inhalation toxicity study (where no grossly observable systemic changes were found at necropsy) combined with the low water solubility of Heavy Fuel Oil Components suggests that uptake across the lung is low. This is supported by physicochemical considerations (ECHA, 2008). No information was located on the uptake and subsequent in vivo fate of Heavy Fuel Oil Components following inhalation exposure to aerosol or vapour.
With regard to uptake after ingestion, modelled information indicates that the majority of hydrocarbon substances present in Heavy Fuel Oil Components have a predicted log Pow of >5 suggesting that uptake by micellar solubilisation is possible (ECHA, 2008). The extent of uptake is uncharacterised however, but oral LD50 values in the range 4 g/kg bw/d to >25 g/kg bw/d suggests either that this is low, or that the absorbed components are of low intrinsic toxicity. No information was located on the metabolism and subsequent fate of Heavy Fuel Oil Components in vivo after ingestion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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